PI3K/AKT信号通路与心力衰竭

被引：68

作者：

范亮亮 ^{[1
]}

马立宁 ^{[2
]}

彭元亮 ^{[1
]}

项荣 ^{[1
]}

机构：

[1] 中南大学生命科学学院

[2] 海南省人民医院

来源：

生命科学研究 | 2015年 / 19卷 / 01期

基金：

中央高校基本科研业务费专项资金资助;

关键词：

心力衰竭; 磷脂酰肌醇3-激酶(PI3K); 丝氨酸/苏氨酸激酶(AKT); 信号通路;

D O I：

10.16605/j.cnki.1007-7847.2015.01.017

中图分类号：

R541.62 [];

学科分类号：

摘要：

丝氨酸/苏氨酸激酶(serine/threonine kinase,AKT)是真核细胞中参与细胞信号转导的关键分子。目前已经证实PI3K(phosphatidylinositol-3-kinase,PI3K)/AKT信号通路在人类肿瘤、代谢紊乱、肾脏疾病以及精神障碍等疾病中发挥着重要的作用。近年来的研究还发现PI3K/AKT信号通路的激活会对心肌细胞的生长、代谢以及凋亡等活动产生影响,且该通路及其中的很多受体、激酶被证实与心力衰竭关系密切,这使该信号通路在心力衰竭的发病机制、诊断及治疗等方面的研究日益受到重视。总结PI3K/AKT的结构特点、相关信号转导机制及其与心力衰竭的关系将有利于更好地理解心力衰竭的发病机制。

引用

页码：85 / 90

页数：6

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