姜黄素对β淀粉样蛋白诱导的老年性痴呆大鼠小胶质细胞活化的影响

被引：11

作者：

王运良 ^{[1
]}

尹红蕾 ^{[1
]}

娄季宇 ^{[2
]}

韩冰 ^{[1
]}

耿爽 ^{[1
]}

刘亚君 ^{[1
]}

机构：

[1] 解放军第医院神经内科

[2] 郑州大学第二附属医院神经内科

来源：

中华临床医师杂志(电子版) | 2011年 / 5卷 / 19期

关键词：

姜黄素; 阿尔茨海默病; 淀粉样β蛋白; 小神经胶质细胞; 大鼠;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

摘要：

目的探讨姜黄素对β淀粉样蛋白(Aβ)诱导的老年性痴呆(AD)大鼠学习记忆障碍及小胶质细胞活化的影响。方法将Aβ1-40微量注射至大鼠右侧海马,制作AD大鼠模型,干预组给予腹腔注射姜黄素连续7d,造模1个月后进行Morris水迷宫试验测定大鼠学习记忆能力,分为空白对照组、对照组和姜黄素给药组。免疫组织化学方法检测小胶质细胞。结果 AD对照组大鼠较空白对照组逃避潜伏期延长,而跨越原平台位置次数明显减少;姜黄素给药组大鼠较AD对照组第2～5天平均逃避潜伏期明显缩短,与空白对照组比较无明显差异(P>0.05),跨越原平台位置次数明显增多,与空白对照组无明显差异(P>0.05),表明姜黄素干预后AD大鼠空间学习、记忆能力明显改善。与空白对照组相比,AD对照组大鼠脑组织海马区可见小胶质细胞表达明显增多(P<0.05);姜黄素组大鼠脑组织海马区小胶质细胞较AD对照组明显减少(P<0.05)。结论姜黄素能够改善Aβ1-40诱导的AD模型大鼠空间学习记忆障碍,其机制可能与抑制Aβ所致小胶质细胞活化有关。

引用

页码：5578 / 5582

页数：5

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