核糖核苷酸还原酶小亚基M2在肿瘤中表达及意义的研究进展

被引：8

作者：

王兆永 ^{[1
]}

刘佰纯 ^{[1
]}

田晓丰 ^{[2
]}

池琦 ^{[1
]}

魏丽娟 ^{[1
]}

王春田 ^{[1
]}

曹宏 ^{[2
]}

机构：

[1] 吉林大学第二医院

[2] 吉林大学中日联谊医院

来源：

中国实验诊断学 | 2014年 / 02期

关键词：

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

<正>核糖核苷酸还原酶(Ribonucleotide Reductase.RR)在DNA合成、修复及细胞增殖中起关键作用,近来被认为是癌症治疗的重要靶点。RR包含3个亚单位,分别是大亚基RRM1、小亚基RRM2和小亚基p53R2。RRM2亚基不仅和DNA的合成密切相关,对恶性肿瘤生物学行为、转移潜能和肿瘤耐药的产生都具有影响.在绒癌、胰腺癌、膀胱癌、胃癌、直肠癌、乳腺癌等多种人体癌组织中发现RRM2的表达水平有异常升高的情况,抑制RRM2的高表达,可以降低酶的活性,抑制癌细胞的生长,增

引用

页码：341 / 344

页数：4

共 9 条

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