骨骼肌纤维化的细胞与分子机制研究进展

被引:24
作者
邓修元 [1 ]
吴志彬 [2 ]
杨忠 [3 ]
机构
[1] 第三军医大学学员旅一队
[2] 第三军医大学大坪医院康复理疗科
[3] 第三军医大学检验系临床血液学教研室
关键词
骨骼肌; 纤维化; 肌卫星细胞; 肌成纤维细胞; 转化生长因子β; 综述;
D O I
暂无
中图分类号
R329 [人体组织学];
学科分类号
100107 [人体解剖与组织胚胎学(人体解剖学、组织与胚胎学)];
摘要
骨骼肌是具有完全再生能力的组织,在急性创伤性损害后骨骼肌多能完成再生修复。当出现慢性退行性病变如进行性肌营养不良和反复肌纤维损伤时,骨骼肌修复过程常伴随着纤维化的发生。通过近十余年来对骨骼肌纤维化机制的研究,发现多种细胞和系列调控分子参与该过程,特别是肌卫星细胞来源的肌成纤维细胞等相关细胞和转化生长因子β(TGF-β)等促纤维化发展的生长因子。本文就骨骼肌纤维化的细胞分子机制及相关拮抗策略进行综述。
引用
收藏
页码:142 / 147
页数:6
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