多药耐药相关蛋白在胃癌中表达的意义

被引：12

作者：

陈金联

吴云林

周同

王瑞年

翟祖康

机构：

[1] 上海第二医科大学附属瑞金医院消化科!上海市第六人民医院消化内镜室

[2] 上海第二医科大学附属瑞金医院消化科!

[3] 上海第二医科大学附属瑞金医院肾脏科!

[4] 上海第二医科大学附属瑞金医院病理教研室!

来源：

上海第二医科大学学报 | 1997年 / 04期

关键词：

耐药相关蛋白; 胃癌; 免疫组化; 预后;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

100214 ;

摘要：

应用免疫组化LSAB法对52例胃癌患者检测耐药相关蛋白（MRP）在胃癌组织中的表达。结果发现52例胃癌中20例阳性，阳性表达率为38．5％。MRP在肿瘤细胞膜上和胞浆内均有表达，且以胞浆内（粗颗粒状）更明显。晚期胃癌（Ⅲ、Ⅳ期）阳性率为60％，显著高于Ⅰ、Ⅱ期早期胃癌的18．5％表达率（P＜0．01）。MRP阳性者平均生存期（20．9±20．7月）和5年生存率（10％）显著低于阴性者（分别为48．5±22．7月与65．6％，均P＜0．01）。提示，MRP在胃癌中的表达与预后密切相关，其可能是内源性耐药的重要机制之一。

引用

页码：247 / 250

页数：4

共 10 条

[1]

The human multidrug resistance - associated protein MRP is a plasma membrane drug effiux pump. Zaman GJR,F1ens MJ,van leusdsen MR,et al. Proceedings of the National Academy of Sciences of the United States of America . 1994

[2]

overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Cole SPC,Bhardwaj G,Ger1ach JH,et al. Science . 1992

[3]

Detection of the Mr 190,000 multidrug resistance protein, MRP,with monoclonal antibodies. Hipfner DR,Gauldie SD,Deely RG,et al. Cancer Research . 1994

[4]

Biochemistry of multidrug resistance mediated by the multidrug transporter. Gottesman MM,Pastan I. Annual Review of Biochemistry . 1993

[5]

Expression of multidrug resistance- associated protein in NIH/3 T3 ce11s confers mu1tidrug resistance associated with increased drug efflux and altered intracellular drug distribution. Breuninger LM,Paul S,GaughanK,et al. Cancer Research . 1995

[6]

The mrp gene associated with a non - P- glycoprotein multidrugresistance encodes a 190- kDa membrane bound glycoprotein. Krishnamachary N,Center MS. Cancer Research . 1993

[7]

Expression of the multidrug resistance- associateted protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma. Bordow SB,Haber M,Madafiglio J,et al. Cancer Research . 1994

[8]

Relationship of P- glycoprotein and carcinoembryonic antigen expression in human colon carcinoma to local invasion, DNA ploid and disease relapse. Sinocrope FA,Hart J,Brasitus TA,et al. Cancer . 1994

[9]

Expression of the multidrug resistance- associated protein (MRP) gene in non- small ds cell lung cancer. Ota E,Abe Y,Oshika,et al. British Journal of Cancer . 1995

[10]

Leukemia[P]. 英国专利:GB0221802D0,2002-10-30

← 1 →