Aβ-Cu(Ⅱ)神经毒性及Cu(Ⅱ)螯合剂的缓解机制

被引：2

作者：

徐魏

黄汉昌

姜招峰

机构：

[1] 北京联合大学应用文理学院

[2] 北京联合大学生物活性物质与功能食品北京市重点实验室

来源：

生命的化学 | 2009年 / 29卷 / 04期

关键词：

Aβ-Cu(Ⅱ)复合物; 氯碘羟喹; 姜黄素; DP-109;

D O I：

10.13488/j.smhx.2009.04.030

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

AD患者脑内大量沉积的过渡态金属离子Cu(Ⅱ)能与β-淀粉样蛋白(Aβ)络合形成Aβ-Cu(Ⅱ)复合物,Aβ-Cu(Ⅱ)复合物在脑内聚集形成老年斑,进而对神经元造成损伤被认为是阿尔茨海默病致病机理的关键环节。用于阿尔茨海默病治疗的Cu(Ⅱ)螯合剂是一类能自由透过血脑屏障,络合AD患者脑内过量沉积的Cu(Ⅱ),从而溶解老年斑和缓解神经损伤的小分子活性物质。Cu(Ⅱ)螯合剂是近年来AD治疗策略的研究热点之一。文章综述了Cu(Ⅱ)诱导的Aβ集聚和氧化损伤毒性,总结了几种缓解Aβ-Cu(Ⅱ)复合物神经毒性的Cu(Ⅱ)螯合剂,并对Cu(Ⅱ)螯合剂作为AD治疗药物的研究前景作了展望。

引用

页码：485 / 489

页数：5

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