西洛他唑对多发性脑梗死患者的认知功能和脑血流的影响

被引：10

作者：

杨燕 ^{[1
,2
]}

李宪章 ^{[1
]}

机构：

[1] 济宁医学院附属医院神经内科

[2] 天津医科大学研究生院

来源：

中国全科医学 | 2010年 / 13卷 / 03期

关键词：

多发性脑梗死; 西洛他唑; 认知; 脑血流;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的探讨西洛他唑对多发性脑梗死(MI)患者认知功能及脑血流的影响。方法入选记忆力减退的多发性脑梗死患者62例,均已口服阿司匹林3个月以上。62例患者随机分为对照组和治疗组,治疗组停用阿司匹林,改为口服西洛他唑,规范治疗6个月。治疗前后用简易精神状态检查量表(MMSE)评估临床疗效,行事件相关电位P300、经颅多普勒(TCD)、颈动脉超声、脑单光子发射计算机断层成像术(SPECT)检查。结果与对照组相比,治疗组患者的MMSE总评分有显著改善;P300潜伏期缩短;TCD示平均血流速度(Vm)提高,阻力指数(RI)降低;超声检查示颈总动脉内膜-中层厚度(IMT)无明显变化,血流量增加;脑SPECT示血流灌注增加。结论西洛他唑可改善多发性脑梗死患者的认知功能及脑血流。

引用

页码：228 / 230+234 +234

页数：4

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