茶多酚调节免疫、抑制肿瘤及抗衰老作用的研究

被引：34

作者：

潘喜华

杨隽

郑勇英

叶于薇

董妙珠

肖萍

仲伟鉴

机构：

[1] 上海市疾病预防控制中心!上海

来源：

上海预防医学杂志 | 2000年 / 02期

关键词：

茶多酚; 免疫调节; 抑制肿瘤; 抗衰老;

D O I：

10.19428/j.cnki.sjpm.2000.02.004

中图分类号：

R965 [实验药理学];

学科分类号：

摘要：

[目的]　研究茶叶中主要的功效成分-茶多酚的抗肿瘤、免疫调节及抗衰老的作用及其机理。[方法]　茶多酚溶解在蒸馏水中,动物经口给予受试物,剂量为0.16g/kg、0.33g/kg、1g/kg体重。免疫调节、抗肿瘤及抗氧化实验均采用ICR小鼠,抗氧化实验同时做果蝇生存实验。[结果]　茶多酚组小鼠NK细胞的活性、巨噬细胞的吞噬能力显著高于对照组;对S180瘤的抑瘤率、接种EAC(艾氏腹水癌)小鼠的平均生存时间,茶多酚组显著高于对照组;茶多酚组小鼠血清超氧化物歧化酶(T-SOD)活力显著高于对照组,丙二醛(MDA)含量显著下降,果蝇的半数死亡时间(LT50)及平均最高寿命显著延长。[结论]　茶多酚具有免疫调节、抑制肿瘤、抗衰老的生物学功能,而且这三方面的作用密切相关。

引用

页码：9 / 11

页数：3

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