地黄寡糖改善HepG2细胞胰岛素抵抗的分子机制研究

被引：18

作者：

张汝学 ^{[1
]}

贾正平 ^{[1
]}

李茂星 ^{[1
]}

王娟 ^{[1
]}

郭丽民 ^{[2
]}

张小华 ^{[1
]}

机构：

[1] 兰州军区兰州总医院国家中医药管理局

[2] 甘肃省疾病预防控制中心

来源：

中草药 | 2008年 / 08期

关键词：

地黄寡糖; HepG2; 胰岛素抵抗; 过氧化物酶体增殖物激活受体α(PPAR-α); 葡萄糖转运蛋白2(GLUT2);

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

1008 ;

摘要：

目的研究地黄寡糖改善HepG2细胞胰岛素抵抗的分子机制。方法运用RT-PCR技术,检测地黄寡糖对胰岛素抵抗HepG2细胞内过氧化物酶体增殖物激活受体α(PPAR-α)、胰岛素受体(IR)、葡萄糖转运蛋白4(GLUT4)和2(GLUT2)基因表达的影响。结果地黄寡糖能够促进胰岛素抵抗HepG2细胞中PPAR-α、IR、GLUT4 mRNA的表达;能够明显降低GLUT2基因mRNA的表达。结论地黄寡糖对HepG2胰岛素抵抗具有明显的改善作用,其机制可能与激活PPAR-α、调节HepG2内IR及GLUT2 mRNA的表达有关。

引用

页码：1184 / 1187

页数：4

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