双环醇对扑热息痛引起小鼠肝脏能量代谢和线粒体功能障碍的影响

被引：47

作者：

李烨

戴国炜

李燕

刘耕陶

机构：

[1] 中国医学科学院、中国协和医科大学药物研究所

来源：

药学学报 | 2001年 / 10期

关键词：

双环醇; 扑热息痛(对乙酰氨基酚); 31P磁共振波谱学(31PMRS); 线粒体; 能量代谢;

D O I：

10.16438/j.0513-4870.2001.10.001

中图分类号：

R965 [实验药理学];

学科分类号：

摘要：

目的　研究双环醇对扑热息痛 (对乙酰氨基酚 )引起小鼠肝能量代谢紊乱和线粒体功能障碍的保护作用。方法　小鼠ip扑热息痛 12 0mg·kg- 1 引起急性肝损伤 ,观察血清谷丙转氨酶 (ALT)和谷草转氨酶 (AST)水平、肝活体磷谱、肝线粒体膜流动性及线粒体ATPase活性的改变。结果　双环醇可显著抑制扑热息痛中毒小鼠PME ATP及PME PDE的升高。双环醇 (2 0 0mg·kg- 1 )可显著降低扑热息痛导致的线粒体膜流动性下降 ,并对线粒体ATPase活性降低有显著保护作用。结论　双环醇可保护扑热息痛导致的急性肝损伤 ,使肝脏能量代谢和磷脂代谢趋于正常 ,并对损伤的线粒体功能有显著的保护作用

引用

页码：723 / 726

页数：4

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