炎症性肠病的遗传学研究进展

[1] Crohn’s disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. Bonen DK,Ogura Y,Nicolae DL,et al. Gastroenterology . 2003

[2] Genetic markers may predict disease behavior in patients with ulcerative colitis. Roussomoustakaki M,Satsangi J,Welsh K,et al. Gastroenterology . 1997

[3] Surgical stress shifts the intestinal Escherichia coli population to that of a more adherent phenotype: role in barrier regulation. Rocha F,Laughlin R,Musch MW,et al. Journal of Surgery . 2001

[4] The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Cuthbert AP,Fisher SA,Mirza MM,et al. Gastroenterology . 2002

[5] Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Rioux JD,Silverberg MS,Daly MJ,et al. The American Journal of Human Genetics . 2000

[6] Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn’s disease. Neut C,Bulois P,Desreumaux P,et al. The American journal of Gastroenterology . 2002

[7] CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Lesage S,Zouali H,Cezard JP,et al. The American Journal of Human Genetics . 2002

[8] CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Hisamatsu T,Suzuki M,Reinecker HC,et al. Gastroenterology . 2003

[9] Inflammatory bowel disease in 67 families each with three or more affected first-degree relatives. Lee JC,Lennard-Jones JE. Gastroenterology . 1996

[10] TNF-alpha and IFNgamma regulate the expression of the NOD2 (CARD15 ) gene in human intestinal epithelial cells. Rosenstiel P,Fantini M,Brautigam K,et al. Gastroenterology . 2003

[1] Crohn’s disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. Bonen DK,Ogura Y,Nicolae DL,et al. Gastroenterology . 2003

[2] Genetic markers may predict disease behavior in patients with ulcerative colitis. Roussomoustakaki M,Satsangi J,Welsh K,et al. Gastroenterology . 1997

[3] Surgical stress shifts the intestinal Escherichia coli population to that of a more adherent phenotype: role in barrier regulation. Rocha F,Laughlin R,Musch MW,et al. Journal of Surgery . 2001

[4] The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Cuthbert AP,Fisher SA,Mirza MM,et al. Gastroenterology . 2002

[5] Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Rioux JD,Silverberg MS,Daly MJ,et al. The American Journal of Human Genetics . 2000

[6] Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn’s disease. Neut C,Bulois P,Desreumaux P,et al. The American journal of Gastroenterology . 2002

[7] CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Lesage S,Zouali H,Cezard JP,et al. The American Journal of Human Genetics . 2002

[8] CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Hisamatsu T,Suzuki M,Reinecker HC,et al. Gastroenterology . 2003

[9] Inflammatory bowel disease in 67 families each with three or more affected first-degree relatives. Lee JC,Lennard-Jones JE. Gastroenterology . 1996

[10] TNF-alpha and IFNgamma regulate the expression of the NOD2 (CARD15 ) gene in human intestinal epithelial cells. Rosenstiel P,Fantini M,Brautigam K,et al. Gastroenterology . 2003