类风湿关节炎易感基因遗传背景的研究进展

被引：29

作者：

刘玮 ^{[1
]}

吴歆 ^{[2
]}

徐沪济 ^{[2
]}

机构：

[1] 中国人民解放军南京军区福州总医院呼吸与危重症医学科

[2] 中国人民解放军海军军医大学附属长征医院风湿免疫科

来源：

诊断学理论与实践 | 2018年 / 17卷 / 03期

关键词：

类风湿关节炎; 遗传背景; 机制;

D O I：

10.16150/j.1671-2870.2018.03.024

中图分类号：

R593.22 [类风湿性关节炎];

学科分类号：

100201 [内科学];

摘要：

<正>类风湿关节炎（rheumatoid arthritis,RA）是以持续性滑膜炎、全身性炎症以及出现自身抗体为特征的一组疾病,其中自身抗体主要以类风湿因子和抗环瓜氨酸肽抗体（anticitrullinated protein antibody,ACPA）为代表[1]。RA是常见的风湿性疾病之一,在我国其患病率为0.2%0.4%[2]。该病病程迁延,致残率高,可导致患者的寿命平均缩短10～15年。近

引用

页码：347 / 351

页数：5

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