Notch信号通路研究进展

被引：11

作者：

王利祥

华子春

机构：

[1] 南京大学医药生物技术国家重点实验室

来源：

中国医药生物技术 | 2009年 / 4卷 / 03期

关键词：

信号通路; 配体; 结构域; 信号途径; 介导; Notch; 体胞; 重复序列; NICD; 调控机制; 信号传递;

D O I：

暂无

中图分类号：

R341 [];

学科分类号：

1001 ;

摘要：

<正>1917年,Morgan及其同事在果蝇体内发现一种基因,因其功能部分缺失可导致果蝇翅缘出现缺口,故命名该基因为Notch。随后的研究发现,Notch从无脊椎动物到脊椎动物的多个物种中表达,其家族成员的结构具有高度保守性,

引用

页码：224 / 226

页数：3

共 12 条

[1] The Notch pathway in prostate development and cancer [J].

Leong, Kevin G. ;

Gao, Wei-Qiang .

DIFFERENTIATION, 2008, 76 (06) :699-716

[2]

Regulation of angiogenesis by homotypic and heterotypic notch signalling in endothelial cells and pericytes: from basic research to potential therapies[J] . Richard C. A. Sainson,Adrian L. Harris.Angiogenesis . 2008 (1)

[3] Neuralized contains a phosphoinositide-binding motif required downstream of ubiquitination for Delta endocytosis and Notch signaling [J].

Skwarek, Lara C. ;

Garroni, Michael K. ;

Commisso, Cosimo ;

Boulianne, Gabrielle L. .

DEVELOPMENTAL CELL, 2007, 13 (06) :783-795

[4] Direct regulation of Gata3 expression determines the T helper differentiation potential of notch [J].

Amsen, Derk ;

Antov, Andrey ;

Jankovic, Dragana ;

Sher, Alan ;

Radtke, Freddy ;

Souabni, Abdallah ;

Busslinger, Meinrad ;

McCright, Brent ;

Gridley, Thomas ;

Flavell, Richard A. .

IMMUNITY, 2007, 27 (01) :89-99

[5] Abnormal vertebral segmentation and the notch signaling pathway in man [J].

Turnpenny, Peter D. ;

Alman, Ben ;

Cornier, Alberto S. ;

Giampietro, Philip F. ;

Offiah, Amaka ;

Tassy, Olivier ;

Pourquie, Olivier ;

Kusumi, Kenro ;

Dunwoodie, Sally .

DEVELOPMENTAL DYNAMICS, 2007, 236 (06) :1456-1474

[6] The Notch1/c-Myc pathway in T cell leukemia [J].

Sharma, Vishva Mitra ;

Draheim, Kyle M. ;

Kelliher, Michelle A. .

CELL CYCLE, 2007, 6 (08) :927-930

[7] Regulation of peripheral B cell maturation [J].

Thomas, Matthew D. ;

Srivastava, Bhaskar ;

Allman, David .

CELLULAR IMMUNOLOGY, 2006, 239 (02) :92-102

[8]

Roles of O ‐Fucosyltransferase 1 and O ‐Linked Fucose in Notch Receptor Function[J] . Tetsuya Okajima,Tsukasa Matsuda.Methods in Enzymology . 2006

[9] The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila [J].

Fuwa, TJ ;

Hori, K ;

Sasamura, T ;

Higgs, J ;

Baron, M ;

Matsuno, K .

MOLECULAR GENETICS AND GENOMICS, 2006, 275 (03) :251-263

[10] The intracellular domain of Notch ligand Delta1 induces cell growth arrest [J].

Kolev, V ;

Kacer, D ;

Trifonova, R ;

Small, D ;

Duarte, M ;

Soldi, R ;

Graziani, I ;

Sideleva, O ;

Larman, B ;

Maciag, T ;

Prudovsky, I .

FEBS LETTERS, 2005, 579 (25) :5798-5802

← 1 2 →