细胞色素C评价心肌细胞凋亡的研究进展

被引：10

作者：

杨泽栋

李永东

机构：

[1] 内蒙古医学院第三附属医院心内科

来源：

医学综述 | 2012年 / 18卷 / 03期

关键词：

细胞色素C; 心肌细胞凋亡; 研究进展;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

摘要：

细胞色素C(Cyt C)是呼吸链的电子载体,线粒体释放的Cyt C不仅进入细胞质诱导凋亡,而且也由凋亡细胞释放到细胞外。缺氧、缺血可致心肌细胞线粒体中Cyt C大量释放导致心肌细胞凋亡,心肌细胞凋亡加重时,Cyt C胞质表达增多,抑制心肌细胞凋亡时Cyt C胞质表达也同时减少。血清Cyt C含量的变化可以反映心肌细胞凋亡程度的改变。

引用

页码：341 / 344

页数：4

共 15 条

[1]

Role of mitochondrial ion channels in cell death [J].

Ryu, Shin-Young ;

Peixoto, Pablo M. ;

Teijido, Oscar ;

Dejean, Laurent M. ;

Kinnally, Kathleen W. .

BIOFACTORS, 2010, 36 (04) :255-263

[2]

Cytochrome c biogenesis: the Ccm system [J].

Sanders, Carsten ;

Turkarslan, Serdar ;

Lee, Dong-Woo ;

Daldal, Fevzi .

TRENDS IN MICROBIOLOGY, 2010, 18 (06) :266-274

[3]

Circulating Cytochrome c as Potential Biomarker of Impaired Reperfusion in ST-Segment Elevation Acute Myocardial Infarction [J].

Marenzi, Giancarlo ;

Giorgio, Marco ;

Trinei, Mirella ;

Moltrasio, Marco ;

Ravagnani, Paolo ;

Cardinale, Daniela ;

Ciceri, Fabio ;

Cavallero, Annalisa ;

Veglia, Fabrizio ;

Fiorentini, Cesare ;

Cipolla, Carlo M. ;

Bartorelli, Antonio L. ;

Pelicci, Piergiuseppe .

AMERICAN JOURNAL OF CARDIOLOGY, 2010, 106 (10) :1443-1449

[4]

Circulating soluble cytochrome c in liver disease as a marker of apoptosis [J].

Ben-Ari, Z ;

Schmilovotz-Weiss, H ;

Belinki, A ;

Pappo, O ;

Sulkes, J ;

Neuman, MG ;

Kaganovsky, E ;

Kfir, B ;

Tur-Kaspa, R ;

Klein, T .

JOURNAL OF INTERNAL MEDICINE, 2003, 254 (02) :168-175

[5]

Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure [J].

Abbate, A ;

Biondi-Zoccai, GGL ;

Bussani, R ;

Dobrina, A ;

Camilot, D ;

Feroce, F ;

Rossiello, R ;

Baldi, F ;

Silvestri, F ;

Biasucci, LM ;

Baldi, A .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (05) :753-760

[6]

Cytochrome-<Emphasis Type="Italic">c</Emphasis> detection.[J].Trevor Alleyne;Jerome Joseph;Valerie Sampson.Applied Biochemistry and Biotechnology.2001, 2

[7]

Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c [J].