乙型肝炎肝硬化抗病毒治疗研究进展

被引：71

作者：

黄英男

吴昊

沈锡中

机构：

[1] 复旦大学附属中山医院消化科

来源：

复旦学报(医学版) | 2013年 / 40卷 / 02期

关键词：

干扰素(IFN); 核苷类似物(NUCs); 乙型肝炎病毒; 肝硬化;

D O I：

暂无

中图分类号：

R512.62 [];

学科分类号：

摘要：

慢性乙肝病毒感染是全世界主要的公共卫生问题之一,每年有约3%的慢性乙型肝炎患者发展为肝硬化。若无有效的抗病毒治疗手段,这些乙肝患者会发展为失代偿期肝硬化或肝细胞癌。对于肝硬化患者,干扰素(interferon,IFN)和核苷类似物[nucleos(t)ide analogues,NUCs]是重要的抗病毒药物。IFN能抑制乙肝病毒复制并调节免疫功能,但不良反应较大,仅可用于情况较好的代偿期肝硬化患者;NUCs包括拉米夫定、阿德福韦酯、恩替卡韦、替比夫定及替诺福韦酯,能够抑制病毒复制,减少肝硬化患者远期并发症的发生,不良反应小但容易发生病毒耐药。本文对乙肝肝硬化的抗病毒治疗新进展作一综述。

引用

页码：233 / 238

页数：6

共 15 条

[1]

Rhabdomyolysis in a 48-Year-Old Man With Hepatitis B-Induced Cirrhosis [J].

Dang, Shuangsuo ;

Gao, Ning ;

Zhang, Xin ;

Jia, Xiaoli .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2011, 342 (01) :73-75

[2]

716 FIVE-YEAR TELBIVUDINE TREATMENT WITH EFFECTIVE VIRAL SUPPRESSION RESULTS IN RESOLUTION OF LIVER INFLAMMATION AND FIBROSIS REGRESSION IN PATIENTS WITH CHRONIC HEPATITIS B.[J].J. Hou;D. Xu;G. Shi;Z. Goodman;M. Wan;D. Tan;C. Chen;Q. Xie;L. Wei;J. Niu;Q. Wang;H. Ren;Y. Wang;J. Jia;W. Bao;Y. Dong;A. Trylesinski;N. Naoumov.Journal of Hepatology.2011,

[3]

Treatment with peginterferon versus interferon in Chinese patients with hepatitis B [J].

Yu, Hai-bo ;

Liu, En-qi ;

Lu, She-min ;

Zhao, Si-hai .

BIOMEDICINE & PHARMACOTHERAPY, 2010, 64 (08) :559-564

[4]

Risk assessment for the development of hepatocellular carcinoma: According to on-treatment viral response during long-term lamivudine therapy in hepatitis B virus-related liver disease [J].

Eun, Jong Ryul ;

Lee, Heon Ju ;

Kim, Tae Nyeun ;

Lee, Kyeung Soo .

JOURNAL OF HEPATOLOGY, 2010, 53 (01) :118-125

[5]

Chronic Hepatitis B: Update 2009 [J].

Lok, Anna S. F. ;

McMahon, Brian J. .

HEPATOLOGY, 2009, 50 (03) :661-662

[6]

EASL Clinical Practice Guidelines: Management of chronic hepatitis B [J].

Marcellin, Patrick ;

Dusheiko, Geoffrey ;

Zoulim, Fabien ;

Esteban, Rafael ;

Hadziyannis, Stefanos ;

Lampertico, Pietro ;

Manns, Michael ;

Shouval, Daniel ;

Yurdaydin, Cihan .

JOURNAL OF HEPATOLOGY, 2009, 50 (02) :227-242

[7]

Tenofovir Disoproxil Fumarate versus Adefovir Dipivoxil for Chronic Hepatitis B [J].

Marcellin, Patrick ;

Heathcote, E. Jenny ;

Buti, Maria ;

Gane, Ed ;

de Man, Robert A. ;

Krastev, Zahary ;

Germanidis, George ;

Lee, Sam S. ;

Flisiak, Robert ;

Kaita, Kelly ;

Manns, Michael ;

Kotzev, Iskren ;

Tchernev, Konstantin ;

Buggisch, Peter ;

Weilert, Frank ;

Kurdas, Oya Ovung ;

Shiffman, Mitchell L. ;

Trinh, Huy ;

Washington, Mary Kay ;

Sorbel, Jeff ;

Anderson, Jane ;

Snow-Lampart, Andrea ;

Mondou, Elsa ;

Quinn, Joe ;

Rousseau, Franck .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (23) :2442-2455

[8]

Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial.[J].Harry LA Janssen;Monika van Zonneveld;Hakan Senturk;Stefan Zeuzem;Ulus S Akarca;Yilmaz Cakaloglu;Christopher Simon;Thomas MK So;Guido Gerken;Robert A de Man;Hubert GM Niesters;Pieter Zondervan;Bettina Hansen;Solko W Schalm.The Lancet.2005, 9454

[9]

LOW-DOSE, TITRATABLE INTERFERON-ALFA IN DECOMPENSATED LIVER-DISEASE CAUSED BY CHRONIC INFECTION WITH HEPATITIS-B VIRUS [J].