舌下免疫治疗的免疫学机制

被引：2

作者：

杨宇辉

刘光辉

机构：

[1] 华中科技大学同济医学院附属同济医院过敏反应科

来源：

中华临床免疫和变态反应杂志 | 2010年 / 4卷 / 03期

关键词：

舌下免疫治疗; 皮下免疫治疗; Langerhans样细胞; IgG4; 调节性T淋巴细胞;

D O I：

暂无

中图分类号：

R593.1 [变态反应性疾病];

学科分类号：

摘要：

舌下免疫治疗(sublingual immunotherapy,SLIT)通过舌下途径给予变应原诱导变态反应性疾病患者产生变应原特异性免疫耐受,其疗效和安全性已得到广泛认同。然而,目前对SLIT确切机制的认识仍然有限。一般认为SLIT与皮下免疫治疗(subcutaneous immunotherapy,SCIT)相似,可降低患者体内特异性IgE水平并诱导产生保护性IgG4;同时能抑制患者皮肤黏膜局部炎症效应细胞的募集及活性。SLIT的另一个重要作用是将患者体内Th2型为主的免疫反应转变为Th1型反应。目前越来越多的证据显示调节性T淋巴细胞(regulatory T cell,Treg)参与变态反应性疾病的控制,虽然尚缺乏确切证据,但Treg可能在SLIT中起重要作用。更多Treg与变应原外周免疫耐受之间关系的研究,将有助于SLIT机制的进一步阐明。

引用

页码：221 / 228

页数：8

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