11β-羟基类固醇脱氢酶2与炎性疾病的关系

被引：7

作者：

陈晓琳

王丽娜

王兴友

机构：

[1] 北京军区总医院呼吸内科

来源：

医学综述 | 2011年 / 17卷 / 12期

关键词：

11β-羟基类固醇脱氢酶; 炎症; 糖皮质激素;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

11β-羟基类固醇脱氢酶2(11β-HSD2)是糖皮质激素代谢的关键酶,可以促进有活性的皮质醇转化为可的松,从而降低有活性的糖皮质激素浓度。机体处于患有溃疡性结肠炎、风湿性疾病、呼吸系统炎性疾病等病理状态时,在炎性因子的刺激下11β-HSD2发生变化。炎性刺激可以通过调节11β-HSD2的表达促进细胞内糖皮质激素的活化,提高局部糖皮质激素的浓度,有助于为未来的临床干预提供一个新靶点。

引用

页码：1769 / 1772

页数：4

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