60岁及以上帕金森病患者左旋多巴诱发运动障碍发生率及相关因素分析

被引：9

作者：

李淑华

苏闻

曾湘豫

陈海波

蔡晓杰

机构：

[1] 北京医院神经内科

来源：

中华全科医师杂志 | 2016年 / 15卷 / 01期

关键词：

运动障碍, 药物性; 帕金森病; 左旋多巴;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

摘要：

采用横断面研究对100例以复方左旋多巴为主要治疗的60岁及以上帕金森病患者进行一般状况、用药情况、统一帕金森病评分量表检查及左旋多巴诱发运动障碍(LID)出现率调查。本组患者LID发生率为37%, 服用复方左旋多巴4年以上者LID的发生率高于服用复方左旋多巴4年以下者(55%与26%, χ2=8.770, P=0.003);震颤为主型PD患者"剂峰"运动障碍发生率低于强直少动为主型(χ2=4.399, P=0.036)。LID主要与复方左旋多巴服用时间有关, 金刚烷胺有可能降低"关期"肌张力障碍的发生率。

引用

页码：53 / 55

页数：3

共 6 条

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