不同因子致心肌纤维化分子学机制

被引：32

作者：

王禹川 ^{[1
]}

丁燕生 ^{[2
]}

刘梅林 ^{[1
]}

机构：

[1] 不详

[2] 北京大学第一医院老年科

[3] 不详

[4] 北京大学第一医院心内科

[5] 不详

来源：

医学综述 | 2012年 / 17期

关键词：

心肌纤维化; 血管紧张素Ⅱ; 醛固酮; 转化生长因子β; 炎性因子; 氧自由基; 结缔组织生长因子;

D O I：

暂无

中图分类号：

R541 [心脏疾病];

学科分类号：

摘要：

心肌纤维化不仅是各种心脏病变引发的结果,还是多种心脏病变的诱因。在心肌纤维化发生过程中,涉及多种因子参与,其中主要包括血管紧张素Ⅱ、醛固酮、转化生长因子β、各种炎性因子、氧自由基和结缔组织生长因子等。这些因子通过不同或相同的信号通路途径介导心肌纤维化的发生,详细了解相关机制有助于寻找防治心肌纤维化发生的干预靶点,有利于心脏疾病的一级预防和二级预防。

引用

页码：2736 / 2740

页数：5

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