银杏叶提取物对帕金森病大鼠黑质细胞的保护作用

被引:4
作者
曹非
曹学兵
孙圣刚
王涛
梅元武
童萼塘
骆芳
机构
[1] 华中科技大学同济医学院附属协和医院神经内科
关键词
银杏叶提取物; 帕金森病; 自由基; 细胞凋亡;
D O I
暂无
中图分类号
R285.5 [中药实验药理];
学科分类号
摘要
目的 观察细胞凋亡在帕金森病发病过程中的作用 ,探讨银杏叶提取物用于帕金森病防治的可能性。方法 通过 6 OHDA脑立体定向注射术建立大鼠帕金森病模型 ,采用生化、TUNEL、电镜的方法观察帕金森病大鼠模型制作后 1、7、14、2 1d黑质细胞自由基 (丙二醛、过氧化物歧化酶 )、细胞凋亡数变化及超微结构的改变 ,同时观察使用银杏叶提取物 (EGb组 )治疗对上述指标的影响。结果 在大鼠帕金森病发病过程中PD组、EGb组大鼠黑质丙二醛 (MDA)、过氧化物歧化酶 (SOD)、细胞凋亡数随时间增加而升高 ,PD组大鼠各指标均高于EGb组 (P <0 .0 5 ) ,PD组黑质细胞超微结构改变符合典型的凋亡改变。结论 细胞凋亡参与了帕金森病发病 ,银杏叶能有效减轻大鼠帕金森病发病过程中黑质细胞损伤
引用
收藏
页码:396 / 399
页数:4
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