血尿酸与2型糖尿病及并发冠心病的关系

被引：34

作者：

雒瑢

樊继援

机构：

[1] 天津医科大学总医院内分泌科

来源：

中国糖尿病杂志 | 2006年 / 01期

关键词：

尿酸; 糖尿病,2型; 冠状动脉性心脏病;

D O I：

暂无

中图分类号：

R587.1 [糖尿病]; R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

目的探讨血尿酸(SUA)水平与2型糖尿病(T2DM)及T2DM并发冠心病的关系和SUA的影响因素。方法80例T2DM患者(DM组)、92例T2DM并发冠心病患者(DC组)及119例健康查体者(NC组),均检测SUA。结果(1)SUA水平NC组为280±81 mmol/L、DM组257±76 mmol/L,DC组302±72 mmol/L;DM组的SUA水平较NC组(P=0.037)、DC组(P=0.000)明显降低,DC组较NC组SUA水平有升高趋势(P=0.050);(2)男性SUA水平高于女性(t=3.330,P=0.001);(3)男性腰臀比(R=0.354)为SUA的独立影响因素;女性年龄(R=0.623)和体质指数(R=0.286)为SUA的独立影响因素;(4)高尿酸血症是T2DM并发冠心病的独立危险因素,并与吸烟和高血压有协同作用。结论DM组患者较NC组SUA水平下降,而相同病程的T2DM并发冠心病患者SUA反而升高;男性SUA高于女性,且两性SUA的影响因素不同。

引用

页码：20 / 22

页数：3

共 7 条

[1]

Serum uric acid for short-term prediction of cardiovascular disease incidence in the Gubbiopopulation Study. Puddu PE,Lanti M,Menotti A,et al. Acta Cardiologica . 2001

[2]

Hypouricemia andhyperuricemia in type 2 diabetes:two different phenotypes. Bo S,Cavallo-Perin P,Gentile L,et al. European Journal of Clinical Investigation . 2001

[3]

Serum uric acidas an independent predictor of mortality in patients with angio-graphically proven coronary artery disease. Bickel C,Rupprecht HJ,Blankenberg S,et al. The American Journal of Cardiology . 2002

[4]

Atherosclerosis[P]. DONG CHUNMING;GOLDSCHMIDT PASCAL J.中国专利:US2008095751A1,2008-04-24

[5]

Relationship betweenfasting insulin and cardiovascular risk factors is already present inyoung men:the Verona Young Men Atherosclerosis Risk FactorStudy. Bonora E,Targher G,Zenere MB,et al. European Journal of Clinical Investigation . 1997

[6]

Serum urate as an antioxi-dant for ascorbic acid. Sevanian A,Davies K,Hochstein P. The American Journal of Clinical Nutrition . 1991

[7]

Circadian varia-tion in oxidative stress markers in healthy and type II diabeticmen. Kanabrocki EL,Murray D,Hermida RC,et al. Chronobiology International . 2002

← 1 →