治疗痛风和高尿酸血症药物研究进展

被引：108

作者：

陈光亮

周媛凤

张颖

机构：

[1] 安徽中医药大学中西医结合临床学院

来源：

中国临床药理学与治疗学 | 2017年 / 22卷 / 01期

关键词：

痛风; 高尿酸血症; 治疗药物; 研究进展;

D O I：

暂无

中图分类号：

R589.7 [嘌呤（Purine）代谢障碍];

学科分类号：

100201 [内科学];

摘要：

对急性痛风性关节炎的治疗,与常规剂量治疗方案相比,小剂量秋水仙碱或小剂量秋水仙碱+非甾体抗炎药治疗方案疗效相近,而安全性却大幅度提高。IL-1R拮抗剂阿那白滞素、利纳西普、康奈单抗等能有效缓解痛风急性期的症状,已成为第四类抗急性痛风的药物。别嘌呤醇的严重超敏反应综合征与肾功能、开始剂量、HLA-B*5801基因有关。非布司他、托匹司他、ulodesine、lesinurad、RDEA-3170、尿酸酶是近年来新型的降低尿酸药物。

引用

收藏

页码：104 / 109

页数：6

相关论文

共 16 条

[1]

119例重症药疹的回顾性分析 [J].

汪琳 ;

邱晓燕 .

中国临床药理学与治疗学, 2014, 19 (08) :885-889

[2]

小剂量与常规剂量秋水仙碱治疗急性痛风性关节炎的系统评价 [J].

蒙龙 ;

李娟 ;

龙锐 ;

贾运涛 .

中国临床药理学与治疗学, 2014, 19 (06) :656-662

[3]

高尿酸血症和痛风治疗的中国专家共识.[J]..中华内分泌代谢杂志.2013, 11

[4]

Comparison of topiroxostat and allopurinol in Japanese hyperuricemic patients with or without gout: a phase 3, multicentre, randomized, double-blind, double-dummy, active-controlled, parallel-group study [J].

Hosoya, T. ;

Ogawa, Y. ;

Hashimoto, H. ;

Ohashi, T. ;

Sakamoto, R. .

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2016, 41 (03) :290-297

[5]

Clinical efficacy and safety of topiroxostat in Japanese male hyperuricemic patients with or without gout: an exploratory, phase 2a, multicentre, randomized, double-blind, placebo-controlled study [J].

Hosoya, T. ;

Sasaki, T. ;

Hashimoto, H. ;

Sakamoto, R. ;

Ohashi, T. .

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2016, 41 (03) :298-305

[6]

Canakinumab for the Patient With Difficult-to-Treat Gouty Arthritis: Review of the Clinical Evidence.[J].Thomas Bardin.Joint Bone Spine.2015,

[7]

Risk of cutaneous adverse events with febuxostat treatment in patients with skin reaction to allopurinol. A retrospective, hospital-based study of 101 patients with consecutive allopurinol and febuxostat treatment [J].

Bardin, Thomas ;

Chales, Gerard ;

Pascart, Tristan ;

Flipo, Rene-Marc ;

Ea, Hang Korng ;

Roujeau, Jean-Claude ;

Delayen, Aurelie ;

Clerson, Pierre .

JOINT BONE SPINE, 2016, 83 (03) :314-317

[8]

Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout [J].

Hosoya, Tatsuo ;

Ohno, Iwao ;

Nomura, Shinsuke ;

Hisatome, Ichiro ;

Uchida, Shunya ;

Fujimori, Shin ;

Yamamoto, Tetsuya ;

Hara, Shigeko .

CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2014, 18 (06) :876-884

[9]

Mechanism of Action of Colchicine in the Treatment of Gout [J].

Dalbeth, Nicola ;

Lauterio, Thomas J. ;

Wolfe, Henry R. .

CLINICAL THERAPEUTICS, 2014, 36 (10) :1465-1479

[10]

Efficacy of rasburicase (recombinant urate oxidase) in the prevention and treatment of malignancy-associated hyperuricemia: An Indian experience [J].

Digumarti, R. ;

Sinha, S. ;

Nirni, S. S. ;

Patil, S. G. ;

Pedapenki, R. M. .

INDIAN JOURNAL OF CANCER, 2014, 51 (02) :180-183