Visfatin与肥胖及糖尿病关系的研究进展

被引：2

作者：

杨洁瑾

刘伟

机构：

[1] 上海交通大学医学院仁济医院内分泌科

来源：

上海交通大学学报(医学版) | 2008年 / 09期

关键词：

Visfatin/前B细胞集落增强因子; 脂肪细胞因子; 肥胖; 糖尿病; 胰岛素抵抗;

D O I：

暂无

中图分类号：

R587.1 [糖尿病]; R589.2 [脂肪代谢障碍];

学科分类号：

1002 ; 100201 ;

摘要：

内脏脂肪素(Visfatin)是新近发现的一种脂肪细胞因子,以前被称为前B细胞集落增强因子(PBEF)。近来许多研究发现,Visfatin具有类似胰岛素的生物效应,并能促进脂肪细胞的分化、抑制肝糖原的释放和促血管平滑肌细胞成熟。Visfatin水平与糖、脂代谢相关。对于Visfatin的深入研究或许可使其成为糖尿病及代谢综合征治疗的一个新靶点。

引用

页码：1187 / 1190

页数：4

共 12 条

[1] 不同糖耐量个体血浆内脂素水平的变化 [J].

杨媚 ;

杨刚毅 ;

李伶 ;

李清明 ;

阮华玲 ;

阳皓 ;

李钶 ;

孙勤 ;

唐毅 ;

Gunther Boden .

中华内分泌代谢杂志, 2006, (03) :245-247

[2]

Elevated serum levels of visfatin in gestational diabetes: a comparative study across various degrees of glucose tolerance[J] . K. C. Lewandowski,N. Stojanovic,M. Press,S. M. Tuck,K. Szosland,M. Bienkiewicz,M. Vatish,A. Lewinski,G. M. Prelevic,H. S. Randeva.Diabetologia . 2007 (5)

[3] Reduced plasma visfatin/pre-B cell colony-enhancing factor in obesity is not related to insulin resistance in humans [J].

Pagano, Claudio ;

Pilon, Catia ;

Olivieri, Massimiliano ;

Mason, Paola ;

Fabris, Roberto ;

Serra, Roberto ;

Milan, Gabriella ;

Rossato, Marco ;

Federspil, Giovanni ;

Vettor, Roberto .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (08) :3165-3170

[4]

Lipotoxicity, overnutrition and energy metabolism in aging[J] . Marc Slawik,Antonio J. Vidal-Puig.Ageing Research Reviews . 2006 (2)

[5]

Obesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight Loss: An Update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease From the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism[J] . Paul Poirier,Thomas D. Giles,George A. Bray,Yuling Hong,Judith S. Stern,F Xavier Pi-Sunyer,Robert H. Eckel.Circulation . 2006 (6)

[6] The release of the adipocytokine visfatin is regulated by glucose and insulin [J].

Haider, D. G. ;

Schaller, G. ;

Kapiotis, S. ;

Maier, C. ;

Luger, A. ;

Wolzt, M. .

DIABETOLOGIA, 2006, 49 (08) :1909-1914

[7] Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus [J].

Chen, MP ;

Chung, FM ;

Chang, DM ;

Tsai, JCR ;

Huang, HF ;

Shin, SJ ;

Lee, YJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (01) :295-299

[8]

Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin[J] . C. A. Curat,V. Wegner,C. Sengenès,A. Miranville,C. Tonus,R. Busse,A. Bouloumié.Diabetologia . 2006 (4)

[9]

Pre–B-Cell Colony–Enhancing Factor Regulates NAD+-Dependent Protein Deacetylase Activity and Promotes Vascular Smooth Muscle Cell Maturation[J] . Eric van der Veer,Zengxuan Nong,Caroline O’Neil,Brad Urquhart,David Freeman,J Geoffrey Pickering.Circulation Research . 2005 (1)

[10]

Visfatin: Gene expression in isolated adipocytes and sequence analysis in obese WOKW rats compared with lean control rats[J] . Biochemical and Biophysical Research Communications . 2005 (4)

← 1 2 →