T淋巴细胞在缺血-再灌注损伤中的重要作用

被引：5

作者：

饶建华

王学浩

机构：

[1] 南京医科大学第一附属医院肝脏移植中心国家卫生和计划生育委员会活体肝移植重点实验室

来源：

器官移植 | 2014年 / 5卷 / 05期

关键词：

缺血-再灌注损伤; T淋巴细胞; 先天性免疫活化; 辅助性T细胞1; 辅助性T细胞17; 调节性T细胞;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

<正>缺血-再灌注损伤(IRI)可在多种临床环境(器官移植、分段切除)中发生,可以导致缺血器官功能障碍和衰竭。虽然先天性免疫反应在IRI中发挥重要作用,但是T淋巴细胞也参与IRI的发病过程,包括CD4+T淋巴细胞、CD8+T淋巴细胞、γT淋巴细胞等。尤其是抗原特异性T细胞群体,如效应性CD4+T淋巴细胞,包括辅助性T(T helper,Th)1细胞、Th17细胞、调节性T细胞(Treg),在IRI过程可通过抗原非依赖适应性反应激活炎症免疫反应,通过分泌细胞因子和表达共刺激分子,促进或抑制先天性免疫反应或促进组织修

引用

页码：261 / 265

页数：5

共 23 条

[1]

Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury. Sharma A.K.,LaPar D.J.,Zhao Y.,Lau C.L.,Kron I.L.,Laubach V.E.,Li L.,Okusa M.D.,Iwakura Y. American Journal of Respiratory and Critical Care Medicine . 2011

[2]

Type I,BUT Not Type II,Interferon Is Critical in Liver Injury Induced After Ischemia andReperfusion. Zhai Yuan,Qiao Bo,Gao Feng,et al. Hepatology . 2008

[3]

Programmed death-1/B7-H1negative costimulationprotects mouse liver against ischemia and reperfu-sion injury. Ji H,Shen X,Gao F et al. Hepatology . 2010

[4]

Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice. Kono H,Fujii H,Ogiku M,Hosomura N,Amemiya H,Tsuchiya M,Hara M. J Immunol . 2011

[5]

Regulatory T cells arestrong promoters of acute ischemic stroke in mice by inducingdysfunction of the cerebral microvasculature. Kleinschnitz C,Kraft P,Dreykluft A,et al. Blood . 2013

[6]

Netrin-1regulates the inflammatory response of neutrophils and macrophages,and suppresses ischemic acute kidney injury by inhibiting COX-2-mediated PGE2production. Ranganathan P V,Jayakumar C,Mohamed R, et al. Kidney International . 2013

[7] Programmed Death-1/B7-H1 Negative Costimulation Protects Mouse Liver Against Ischemia and Reperfusion Injury [J].

Ji, Haofeng ;

Shen, Xiuda ;

Gao, Feng ;

Ke, Bibo ;

Freitas, Maria Cecilia S. ;

Uchida, Yoichiro ;

Busuttil, Ronald W. ;

Zhai, Yuan ;

Kupiec-Weglinski, Jerzy W. .

HEPATOLOGY, 2010, 52 (04) :1380-1389

[8]

Role of alpha/beta and gamma/delta T cells in renal ischemia-reperfusion injury. Hochegger Kathrin,Sch?tz Tobias,Eller Philipp,Tagwerker Andrea,Heininger Dorothea,Mayer Gert,Rosenkranz Alexander R. American journal of physiology. Renal physiology . 2007

[9]

Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury. Shichita Takashi,Sugiyama Yuki,Ooboshi Hiroaki,Sugimori Hiroshi,Nakagawa Ryusuke,Takada Ichiro,Iwaki Toru,Okada Yasunori,Iida Mitsuo,Cua Daniel J,Iwakura Yoichiro,Yoshimura Akihiko. Nature Medicine . 2009

[10]

Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia. Vanessa H. Brait,Thiruma V. Arumugam,Grant R. Drummond. Journal of Cerebral Blood Flow and Metabolism . 2012

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