肿瘤药物治疗相关恶心呕吐防治中国专家共识(2019年版)

被引:227
作者
姜文奇
巴一
冯继锋
史艳侠
张俊
沈波
邢镨元
机构
[1] 中国抗癌协会肿瘤临床化疗专业委员会
[2] 中国抗癌协会肿瘤支持治疗专业委员会
[3] 中山大学肿瘤防治中心
[4] 天津医科大学肿瘤医院
[5] 江苏省肿瘤医院
[6] 上海交通大学医学院附属瑞金医院
[7] 国家癌症中心中国医学科学院肿瘤医院
基金
广东省科技计划;
关键词
D O I
暂无
中图分类号
R730.5 [肿瘤治疗学];
学科分类号
100214 [肿瘤学];
摘要
<正>恶心、呕吐是肿瘤药物治疗的常见不良反应。在我国,恶心、呕吐的预防和治疗以5-羟色胺(5-hydr oxytryptamine,5-HT)3受体拮抗剂联合地塞米松作为主流方案,但30%的恶心、呕吐仍未获得满意控制,恶心、呕吐依然是困扰和影响患者生活质量的重要因素。肿瘤药物治疗相关恶心、呕吐显著影响患者的生活质量,降低患者抗肿瘤治疗的依从性,从而影响疗效[1]。另外,严重的恶心、呕吐还
引用
收藏
页码:16 / 26
页数:11
相关论文
共 15 条
[1]
甲磺酸多拉司琼与盐酸格拉司琼预防化疗致恶心呕吐的临床对照研究 [J].
赵娅琴 ;
王瑾 ;
刘端祺 ;
刘敏 ;
陈宏 ;
王辛 ;
李志平 ;
侯梅 .
华西药学杂志, 2015, 30 (01) :128-130
[2]
Incidence of chemotherapy-induced nausea and vomiting associated with docetaxel and cyclophosphamide in early breast cancer patients and aprepitant efficacy as salvage therapy. Results from the Spanish Breast Cancer Group/2009-02 study.[J].Antonio Llombart-Cussac;Manuel Ramos;Elsa Dalmau;José A. García-Saenz;Xavier González-Farré;Laura Murillo;Lourdes Calvo;Serafín Morales;Vicente Carañana;Ana González;Luis A. Fernández-Morales;Fernando Moreno;Mª Isabel Casas;Mª del Mar Angulo;Mª Carmen Cámara;A
[3]
5-HT3 receptors as important mediators of nausea and vomiting due to chemotherapy [J].
Navari, Rudolph M. .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2015, 1848 (10) :2738-2746
[4]
Effects of combined netupitant and palonosetron (NEPA); a cancer supportive care antiemetic; on the ECG of healthy subjects: an ICH E14 thorough QT trial.[J].Tulla Spinelli;Cecilia Moresino;Sybille Baumann;Wolfgang Timmer;Armin Schultz.SpringerPlus.2014, 1
[5]
5-Hydroxytryptamine<sub>3</sub> receptor antagonists and cardiac side effects.[J].Louise Brygger;J&oslash;rn Herrstedt.Expert Opinion on Drug Safety.2014, 10
[6]
Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV) [J].
Schwartzberg, Lee ;
Barbour, Sally Y. ;
Morrow, Gary R. ;
Ballinari, Gianluca ;
Thorn, Michael D. ;
Cox, David .
SUPPORTIVE CARE IN CANCER, 2014, 22 (02) :469-477
[7]
The use of olanzapine versus metoclopramide for the treatment of breakthrough chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy [J].
Navari, Rudolph M. ;
Nagy, Cindy K. ;
Gray, Sarah E. .
SUPPORTIVE CARE IN CANCER, 2013, 21 (06) :1655-1663
[8]
Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia [J].
Doggrell, Sheila A. ;
Hancox, Jules C. .
EXPERT OPINION ON DRUG SAFETY, 2013, 12 (03) :421-431
[9]
Management of Chemotherapy-Induced Nausea and Vomiting.[J].Rudolph M. Navari.Drugs.2013, 3
[10]
Combined data from two phase III trials of the NK1 antagonist aprepitant plus a 5HT3 antagonist and a corticosteroid for prevention of chemotherapy-induced nausea and vomiting:: effect of gender on treatment response [J].
Hesketh, PJ ;
Grunberg, SM ;
Herrstedt, J ;
de Wit, R ;
Gralla, RJ ;
Carides, AD ;
Taylor, A ;
Evans, JK ;
Horgan, KJ .
SUPPORTIVE CARE IN CANCER, 2006, 14 (04) :354-360