抗氧化剂与延长寿命的相关性研究进展

被引：23

作者：

吴奇

朱晨星

樊晓兰

杨德英

杨明耀

机构：

[1] 四川农业大学畜禽遗传资源发掘与创新利用四川省重点实验室

来源：

中国药理学与毒理学杂志 | 2016年 / 30卷 / 05期

关键词：

抗氧化剂; 寿命; 衰老; 活性氧类; 氧化损伤;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

氧化损伤理论是当前解释衰老机制的主流理论之一。研究表明,抗氧化剂能够通过清除自由基、调控压力应激相关基因表达及诱导毒物兴奋效应等方式延长动物寿命。但近期的一些研究也指出,此类抗氧化剂可能存在一系列副作用,具有促氧化、致癌和破坏代谢平衡等风险。同时,较低的吸收率和靶向性也限制了大多数抗氧化剂延长寿命的作用。因此,抗氧化剂和延长寿命之间的相关性有待进一步论证。本文综述了近年来抗氧化剂延长寿命的研究进展,为未来相关研究提供参考。

引用

页码：588 / 597

页数：10

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