癫痫大鼠海马中神经肽Y表达的动态观察及其作用探讨

被引：4

作者：

陈丽丽

杨晓苏

肖波

李国良

朱丹彤

李静

梁静慧

机构：

[1] 中南大学湘雅医院神经内科

来源：

中国神经免疫学和神经病学杂志 | 2004年 / 02期

关键词：

癫痫; 大鼠; 神经肽Y; 匹鲁卡品;

D O I：

暂无

中图分类号：

R742.1 [癫痫];

学科分类号：

摘要：

目的　探讨癫痫大鼠海马中神经肽 Y( NPY)表达的动态变化及其作用 ,以及外源性 NPY对癫痫的影响。方法　将 SD大鼠随机分为 4组 ,采用匹鲁卡品 ( PILO)癫痫动物模型及外源性 NPY侧脑室注入干预法 ,并以免疫组织化学染色观察 NPY的表达。结果　癫痫模型组 PILO注射后 ,门区、CA3区、CA1 区的 NPY阳性细胞数表达增多 ,1 2 h达高峰 ,以后逐渐下降 ,60 d又达一高峰 ;海马颗粒细胞层有 NPY异位表达 ,3 d时最明显 ;NPY干预组门区 NPY阳性细胞数较其对照组表达少。结论　 ( 1 )癫痫发作后急性期海马 NPY表达增多及颗粒细胞层出现异位表达 ,与癫痫发作有关 ;( 2 )外源性 NPY有抗癫痫作用。

引用

页码：76 / 79

页数：4

共 9 条

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