前列腺素的血管活性及其与心血管疾病的关系

被引：10

作者：

戴媛媛

陈雪茁

崔亚娇

丁启龙

机构：

[1] 中国药科大学药学医学基础实验教学中心

来源：

药学研究 | 2017年 / 36卷 / 01期

关键词：

前列腺素H2; 前列腺素D2; 前列腺素E2; 前列腺素F2α; 前列腺素I2; 血栓素A2;

D O I：

10.13506/j.cnki.jpr.2017.01.012

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

1002 ; 100201 ;

摘要：

前列腺素(prostaglandin,PG)是一类具有广泛生理活性的内源性化合物,哺乳动物许多组织、细胞都能合成前列腺素。在正常生理状态下,血管释放内皮依赖的血管收缩物质和内皮依赖的血管舒张物质,如:前列环素(PGI2)和血栓素A2(TXA2),它们共同维持着血管张力的平衡。体内产生的前列腺素不仅对心血管系统的生理功能产生作用,而且前列腺素产生异常与某些心血管疾病的发生亦有关。本文主要总结前列腺素所产生的血管效应,并简要阐述心血管疾病中前列腺素的变化。

引用

页码：40 / 43+47 +47

页数：5

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