Th9细胞参与溃疡性结肠炎发病的研究进展

被引:4
作者
田玲琳
霍丽娟
机构
[1] 山西医科大学第一医院消化内科
关键词
溃疡性结肠炎; Th9细胞; 白细胞介素-9;
D O I
暂无
中图分类号
R574.62 [结肠疾病];
学科分类号
100201 [内科学];
摘要
溃疡性结肠炎(ulcerative colitis,UC)是炎症性肠病(infammatory bowel disease, IBD)的主要类型之一,是一种慢性、非特异性、结肠炎症性疾病,易反复发作并需长期维持治疗,其临床特征包括:腹泻、体重丢失、腹痛、发热和便血以及癌变风险。目前认为UC的发病机制是由于环境因素作用于遗传易感个体,引起免疫系统异常激活,肠黏膜屏障破坏,导致结肠黏膜炎性改变,其中T细胞及其分泌的细胞因子参与免疫应答是UC发病机制研究领域的重要课题。Th9细胞是新近发现的T细胞亚群,其所分泌的IL-9已被证实参与多种自身免疫性疾病,现就Th9细胞的分化及其参与UC发病的机制加以综述。
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