大蒜素对大鼠脊髓缺血再灌注损伤的保护作用

被引：5

作者：

王冰

李兵

机构：

[1] 第四军医大学西京医院神经外科

来源：

中华神经外科疾病研究杂志 | 2013年 / 12卷 / 06期

关键词：

缺血再灌注损伤; 神经保护; 线粒体;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

目的研究大蒜素(allicin)在脊髓缺血再灌注损伤中的保护作用及其相关机制。方法实验前1 w实验用SD大鼠预先给予不同浓度大蒜素腹腔注射,每天一次持续7 d,采用肾下腹主动脉阻断法建立脊髓缺血再灌注损伤模型。损伤后24 h通过测定脊髓组织含水量、梗死体积和正常神经元计数评价大鼠脊髓组织损伤程度。采用(Basso-Beattie-Bresnahan,BBB)评分标准对大鼠进行后肢功能评分以反映损伤后运动功能。损伤后4 h和24 h检测线粒体膜电位、活性氧自由基(ROS)含量和线粒体ATP的变化,讨论大蒜素保护作用与线粒体信号通路的关系。结果大蒜素能减轻脊髓缺血再灌注损伤,促进运动功能恢复,抑制线粒体功能障碍。结论大蒜素通过保护线粒体功能发挥对脊髓缺血再灌注损伤的保护作用。

引用

收藏

页码：513 / 516

页数：4

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