大蒜素对豚鼠心房肌电生理的作用

To exploring the effect of Allitridi on anti arrhythmia, cardiac electrophysiological characteristic are detected in guinea pig atrium muscles by intracellular microelectrode technique. Result:The automaticity which adrenalin induces is inhibited at 125 and 625 umol/L. The force of contraction is weakened; the intensity time curve which reflects excitability move towards right after 625 umol/L administration. under 25、125、625 μmol/L, functional refractory period、action potential duration of 50% and 90% repolarization、 sinus cycle longness are extended, a relationship between dose and effect exist at SCL. Conclusion: Automaticity、 excitability and refractoriness not only are inhibited but also action potential durations are extended after Allitridi administration.