内质网应激与胰岛β细胞凋亡的研究进展

被引：4

作者：

张锦航

马丽霞

吕欣

机构：

[1] 山东大学齐鲁儿童医院儿研所

来源：

生命的化学 | 2015年 / 35卷 / 04期

关键词：

内质网应激; 糖尿病; β细胞凋亡;

D O I：

10.13488/j.smhx.20150419

中图分类号：

R587.1 [糖尿病];

学科分类号：

1002 ; 100201 ;

摘要：

胰岛β细胞具有高度发达的内质网,对内质网应激(endoplasmic reticulum stress,ERS)非常敏感。多种因素可以打破内质网稳态,引起蛋白质折叠障碍或错误折叠以及Ca2+代谢紊乱,进一步触发内质网应激。适度的内质网应激有利于细胞内环境的恢复,过度的内质网应激可会导致内质网功能受损,诱导胰岛β细胞凋亡,从而介导糖尿病的发生、发展。本文就内质网应激与胰岛β细胞凋亡的研究进展做一综述。

引用

页码：574 / 578

页数：5

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