药物相关转运蛋白基因多态性的研究进展

被引:5
作者
李丹
章国良
机构
[1] 北京大学医学部基础医学院药理学系
[2] 北京大学医学部基础医学院药理学系 北京
[3] 北京
关键词
药物代谢; 转运蛋白; 多药耐药; 基因多态性;
D O I
暂无
中图分类号
R968 [遗传药理学];
学科分类号
100602 ; 100706 ;
摘要
药物相关转运蛋白不但与肿瘤多药耐药现象密切相关,而且在人体内广泛参与药物的吸收、分布、代谢和排泄等过程。其编码基因的单核苷酸多态性(singlenucleotidepolymorphism,SNP)位点变异可能与药物转运蛋白的表达、转运功能密切相关,决定了临床常见的个体/群体药物反应差异性。本文主要介绍了近年来有关药物相关转运蛋白SNP位点基因多态性,以及与临床常见表型相关性的研究。
引用
收藏
页码:245 / 248
页数:4
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