mTOR信号通路的生物学功能

被引：179

作者：

陈洪菊

屈艺

母得志

机构：

[1] 四川大学华西第二医院儿科

来源：

生命的化学 | 2010年 / 30卷 / 04期

关键词：

mTOR; 凋亡; 自噬; 蛋白质合成;

D O I：

10.13488/j.smhx.2010.04.011

中图分类号：

Q55 [酶];

学科分类号：

070307 [化学生物学];

摘要：

哺乳动物的雷帕霉素靶(mammalian target of rapamycin,mTOR)是一种非典型丝氨酸/苏氨酸蛋白激酶,可整合细胞外信号,磷酸化下游靶蛋白核糖体p70S6激酶,如S6K1及4E-BP1,影响基因转录与蛋白质翻译,从而参与调控细胞生长、增殖等过程。mTOR的生物学功能的多样性,使其成为当今生物学研究的焦点之一。mTOR与蛋白质合成、免疫、细胞运动及代谢、细胞凋亡及自噬等均有联系。

引用

页码：555 / 561

页数：7

共 22 条

[1]

Phosphorylated mTOR Expression is Associated with Poor Prognosis for Patients with Esophageal Squamous Cell Carcinoma [J].

Hirashima, Kotaro ;

Baba, Yoshifumi ;

Watanabe, Masayuki ;

Karashima, Ryu-ichi ;

Sato, Nobutaka ;

Imamura, Yu ;

Hiyoshi, Yukiharu ;

Nagai, Yohei ;

Hayashi, Naoko ;

Iyama, Ken-ichi ;

Baba, Hideo .

ANNALS OF SURGICAL ONCOLOGY, 2010, 17 (09) :2486-2493

[2]

Rescue Immunosuppression With Mammalian Target of Rapamycin Inhibitor Drugs in Liver Transplantation [J].

Martinez, J. M. A. ;

Pulido, L. B. ;

Bellido, C. B. ;

Usero, D. D. ;

Aguilar, L. T. ;

Moreno, J. L. G. ;

Artacho, G. S. ;

Diez-Canedo, J. S. ;

Gomez, L. M. M. ;

Bravo, M. A. G. .

TRANSPLANTATION PROCEEDINGS, 2010, 42 (02) :641-643

[3]

Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism [J].

Kumar, Anil ;

Lawrence, John C., Jr. ;

Jung, Dae Young ;

Ko, Hwi Jin ;

Keller, Susanna R. ;

Kim, Jason K. ;

Magnuson, Mark A. ;

Harris, Thurl E. .

DIABETES, 2010, 59 (06) :1397-1406

[4]

GLUCAGON-LIKE PEPTIDE-1 (GLP-1) PROTECTS AGAINST METHYLGLYOXAL-INDUCED PC12 CELL APOPTOSIS THROUGH THE PI3K/Akt/mTOR/GCLc/REDOX SIGNALING PATHWAY [J].

Kimura, R. ;

Okouchi, M. ;

Fujioka, H. ;

Ichiyanagi, A. ;

Ryuge, F. ;

Mizuno, T. ;

Imaeda, K. ;

Okayama, N. ;

Kamiya, Y. ;

Asai, K. ;

Joh, T. .

NEUROSCIENCE, 2009, 162 (04) :1212-1219

[5]

Signaling Logic of Activity-Triggered Dendritic Protein Synthesis: An mTOR Gate But Not a Feedback Switch [J].

Jain, Pragati ;

Bhalla, Upinder S. .

PLOS COMPUTATIONAL BIOLOGY, 2009, 5 (02)

[6]

Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer [J].

Kim, Kwang Woon ;

Hwang, Misun ;

Moretti, Luigi ;

Jaboin, Jerry J. ;

Cha, Yong I. ;

Lu, Bo .

AUTOPHAGY, 2008, 4 (05) :659-668

[7]

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response [J].

Weichhart, Thomas ;

Costantino, Giuseppina ;

Poglitsch, Marko ;

Rosner, Margit ;

Zeyda, Maximilian ;

Stuhlmeier, Karl M. ;

Kolbe, Thomas ;

Stulnig, Thomas M. ;

Hoerl, Walter H. ;

Hengstschlaeger, Markus ;

Mueller, Mathias ;

Saeemann, Marcus D. .

IMMUNITY, 2008, 29 (04) :565-577

[8]

Activation of the protein p7OS6K via ERK phosphorylation by cholinergic muscarinic receptors stimulation in human neuroblastoma cells and in mice brain.[J]..Toxicology Letters.2008, 1

[9]

Estradiol attenuates the focal cerebral ischemic injury through mTOR/p70S6 kinase signaling pathway [J].

Koh, Phil-Ok ;

Cho, Jae-Hyeon ;

Won, Chung-Kil ;

Lee, Hyo-Jong ;

Sung, Jin-Hee ;

Kim, Myeong-Ok .

NEUROSCIENCE LETTERS, 2008, 436 (01) :62-66

[10]

mTOR信号通路与调节.[J].陈洪菊;李晋辉;屈艺;母得志;.医学分子生物学杂志.2009, 06

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