酒精性肝病动物模型研究进展

被引：39

作者：

周恒 ^{[1
,2
]}

李俊 ^{[1
,3
]}

王华 ^{[1
,2
,3
]}

机构：

[1] 安徽医科大学药学院

[2] 安徽医科大学第一附属医院肿瘤科

[3] 安徽医科大学肝病研究所

来源：

中国药理学通报 | 2016年 / 04期

关键词：

酒精性肝病; 动物模型; 脂肪肝; 肝损伤; 炎症; 纤维化;

D O I：

暂无

中图分类号：

R575 [肝及胆疾病]; R-332 [医用实验动物学];

学科分类号：

100201 [内科学]; 100402 [劳动卫生与环境卫生学];

摘要：

长期饮酒是全世界导致慢性肝病的重要原因,可导致肝硬化和肝癌。缺乏能够完全模拟人类酒精性肝病的动物模型限制了酒精性肝病病理机制的研究。因此,建立或者改进酒精性动物模型对于研究酒精性肝病机制,进而提出治疗方案具有重要意义。目前,使用最广泛的酒精性肝损伤模型有急性酒精灌胃模型、Lieber-De Carli模型、Tsukamoto-French模型和Gao-binge模型等,该文总结并评价了这些酒精性肝病的动物模型,这些动物模型为研究酒精性肝病和开发新的治疗性药物提供了非常有用的研究工具。

引用

页码：468 / 472

页数：5

共 16 条

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