上皮细胞极性改变与乳腺癌的关系

被引：3

作者：

谢淦

杨壹羚

李崖青

付丽

机构：

[1] 天津医科大学附属肿瘤医院乳腺病理研究室教育部乳腺癌防治重点实验室天津市肿瘤防治重点实验室

来源：

中华病理学杂志 | 2013年 / 03期

关键词：

D O I：

暂无

中图分类号：

R737.9 [乳腺肿瘤];

学科分类号：

100214 ;

摘要：

<正>乳腺上皮细胞极性的建立和维持是乳腺发挥正常功能的必要条件。目前的研究显示乳腺上皮细胞极性的改变在乳腺癌的发生发展过程中起着重要作用,我们就乳腺上皮细胞极性的破坏与乳腺癌关系的最新研究进展进行综述。一、上皮极性的概念及功能正常乳腺组织的上皮极性包括细胞极性及组织极性。1.细胞极性:膜蛋白及细胞器沿顶端-基底端轴的不对称分布称为细胞极性,正常的乳腺上皮顶端位于腺管的腔面,基底端位于基底面。这对乳腺上皮发挥分泌、运输、屏障

引用

页码：212 / 214

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