神经肽-Y在蛛网膜下腔出血引起脑血管痉挛中的作用

被引：8

作者：

季鹰

吴建中

赵雅度

机构：

[1] 北京市神经外科研究所,北京市神经外科研究所,北京市神经外科研究所

来源：

中国病理生理杂志 | 1991年 / 04期

关键词：

神经蛋白质类; 脑血管痉挛; 蛛网膜下腔出血; 5-羟色胺; 去甲肾上腺素;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

本实验采用大鼠经额向基底池Willis环处插管注入NPY,NE和5-HT,以γCBF变化为指标,观察它们对脑血管的在体效应。实验发现NPY对脑血管具有很强的收缩作用,以克分子浓度计算NPY引起脑血管收缩比5-HT强10倍,比NE强500倍,并可增加NE,5-HT的缩血管效应。人及大鼠CSF中NPY测定发现:SAH伴有CVS的病人,CSF中NPY达291.1±58pg/ml,与对照组(164±28.00pg/ml)相比,P<0.01;大鼠SAH后CSF中NPY含量从2.1±2.1增至6.0±3.2ng/ml(P<0.01),同时大鼠皮层内NPY含量从9.5±0.8下降至4.8±0.8ng/ml(P<0.01),提示脑神经元分泌的NPY参与了CVS过程,并在维持CVS持续状态方面起重要作用。实验还提示SAH病人CSF中NPY含量变化可以作为观察CVS是否出现的指标。

引用

页码：412 / 416

页数：5

共 8 条

[1]

Measurement of regional blood flow using hydrogen gas generated by electrolysis. Koshu K,et al. Stroke . 1982

[2]

Increased neuropeptida Y concentrations in cerebrospinal fluid from patients with aneurysmal subarachnoid hemorrhage. Suzuki Y,et al. Stroke . 1989

[3]

Effects of neuropeptide Y on contraction, relaxation and membrane potential of rabbit cerebral arteries. Abel PW,et al. Journal of Cardiovascular Pharmacology . 1989

[4]

Neuropeptide Y: A novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Tatemote K,et al. Nature . 1982

[5]

Nerve fibers containing neuropeptide Y in the cerebral vascular bed: immunocytochemistry, radio-immunoassay and vasomotor effects. Edvinsson L,et al. Journal of Cerebral Blood Flow and Metabolism . 1987

[6]

Effects of neuropeptide Y and calcitonin gene-related peptide on local cerebral blood flow in rat striatum. Suzuki Y,et al. Journal of Cerebral Blood Flow and Metabolism . 1989

[7]

Neuropeptid Y and sympathetic vascular control in man. Lundberg J,et al. Regulatory Peptides . 1985

[8]

Characterization of the contractile effect of NPY in the feline cerebral arteries. Edvinsson L,et al. Acta Physiologica Scandinavica . 1985

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