促红细胞生成素:新的心血管系统信号转导分子

被引：3

作者：

肖祥彬

马康华

机构：

[1] 重庆医科大学附属第一医院心血管内科

来源：

心血管病学进展 | 2008年 / 02期

关键词：

促红细胞生成素; 心血管系统;

D O I：

暂无

中图分类号：

R33 [人体生理学];

学科分类号：

1001 ;

摘要：

传统认为促红细胞生成素(EPO)仅作用于造血细胞,最新研究表明它具有一些非造血效应,如在心肌缺血/再灌注时,有抗凋亡、抗炎等作用,认为它是心血管系统一个新的信号转导分子。其心血管保护作用无疑拓展了心血管疾病研究和治疗的新思路。临床上,EPO用于治疗心力衰竭或肾衰性贫血,不仅纠正贫血,而且改善心功能,提高患者的生活质量。但尚需进一步研究EPO心肌保护的分子机制,以阐明其在心血管系统中的治疗作用。

引用

页码：319 / 323

页数：5

共 13 条

[1] Cardioprotective effects of recombinant human erythropoietin in rats with experimental autoimmune myocarditis [J].

Mitsuma, Wataru ;

Ito, Masahiro ;

Kodama, Makoto ;

Fuse, Koichi ;

Kamura, Kazuki ;

Minagawa, Shiro ;

Kato, Kiminori ;

Hanawa, Haruo ;

Toba, Ken ;

Nakazawa, Mikio ;

Aizawa, Yoshifusa .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 344 (03) :987-994

[2]

Erythropoietin protects the infant heartagainst ischemia–reperfusion injury bytriggering multiple signaling pathways[J] . P. Rafiee,Y Shi,J. Su,K. A. Pritchard,J. S. Tweddell,J. E. Baker.Basic Research in Cardiology . 2005 (3)

[3] Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury [J].

Cai, ZQ ;

Manalo, DJ ;

Wei, G ;

Rodriguez, ER ;

Fox-Talbot, K ;

Lu, HS ;

Zweier, JL ;

Semenza, GL .

CIRCULATION, 2003, 108 (01) :79-85

[4] Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway [J].

Tramontano, AF ;

Muniyappa, R ;

Black, AD ;

Blendea, MC ;

Cohen, I ;

Deng, LL ;

Sowers, JR ;

Cutaia, MV ;

El-Sherif, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 308 (04) :990-994

[5] A functional erythropoietin receptor in a rat heart is linked to anti-apoptotic effects [J].

van der Meer, P ;

Lipsic, E ;

Boer, RAC ;

Henning, RH ;

van Veldhuisen, DJ ;

van Gilst, WH .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (06) :330A-330A

[6] Erythropoietin and VEGF exhibit equal angiogenic potential [J].

Jaquet, K ;

Krause, K ;

Tawakol-Khodai, M ;

Geidel, S ;

Kuck, KH .

MICROVASCULAR RESEARCH, 2002, 64 (02) :326-333

[7]

The effect of correction of mild anemia in severe, resistant congestive heart failure using subcutaneous erythropoietin and intravenous iron: a randomized controlled study[J] . Donald S Silverberg,Dov Wexler,David Sheps,Miriam Blum,Gad Keren,Ron Baruch,Doron Schwartz,Tatyana Yachnin,Shoshana Steinbruch,Itzhak Shapira,Shlomo Laniado,Adrian Iaina.Journal of the American College of Cardiology . 2001 (7)

[8]

Activation of the transcription factor NF-κB by the erythropoietin receptor[J] . Thomas Bittorf,Tom Büchse,Tilo Sasse,Robert Jaster,Josef Brock.Cellular Signalling . 2001 (9)

[9] Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain [J].

Sirén, AL ;

Knerlich, F ;

Poser, W ;

Gleiter, CH ;

Brück, W ;

Ehrenreich, H .

ACTA NEUROPATHOLOGICA, 2001, 101 (03) :271-276

[10]

Left ventricular mass index increase in early renal disease: Impact of decline in hemoglobin[J] . Adeera Levin,Christopher R. Thompson,Jean Ethier,Euan J.F. Carlisle,Sheldon Tobe,David Mendelssohn,Ellen Burgess,Kailash Jindal,Brendan Barrett,Joel Singer,Ognjenka Djurdjev.American Journal of Kidney Diseases . 1999 (1)

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