生理药代动力学模型的特征及其国内外研究进展

被引：15

作者：

董宇

赵兰英

吴萍

王阶

机构：

[1] 中国中医科学院广安门医院

来源：

中国实验方剂学杂志 | 2012年 / 18卷 / 01期

关键词：

生理药代动力学; 药物相互作用; 生理药代动力学/药理学;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

介绍生理药代动力学(PBPK)模型的特征及其研究现状。通过Pubmed检索工具,查询国内外相关文献21篇,对PBPK模型的构建、模型特征和应用现状进行了文献整理和分析。目前PBPK模型已经广泛应用于有毒化合物的安全性评价、药物代谢过程研究、代谢酶和转运蛋白对药物代谢的影响、药物-药物相互作用以及新药的研发过程等研究之中。尽管PBPK模型有很多优势,获得了令人鼓舞的评价结果,但其构建需要数学和计算机的支持以及系统生物学、药物化学、药理学和数学、统计学等多学科专业人员合作,做进一步的探索和完善。

引用

页码：247 / 250

页数：4

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