部分黄酮类化合物的Ⅱ相代谢产物及其药理活性研究进展

被引：16

作者：

汤泓

汤丽玲

徐瑞娟

杨劲

机构：

[1] 中国药科大学药物代谢动力学重点实验室

来源：

中国新药杂志 | 2012年 / 21卷 / 02期

关键词：

黄酮类化合物; Ⅱ相代谢产物; 药理活性;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

黄酮类化合物为一大类广泛存在于食物和药物中的天然产物,具有多种药理作用。近来研究表明黄酮类化合物在体内主要以苷元的Ⅱ相代谢产物形式存在,包括不同取代位点的一系列苷元的葡糖醛酸苷、硫酸酯及混合结合物。其中一些Ⅱ相代谢产物已被证明具有抗炎、抗氧化、抗肿瘤、影响代谢酶和转运体等方面的药理活性。文中对文献报道的黄酮、异黄酮、黄酮醇、二氢黄酮、黄烷-3-醇和花色素等黄酮类化合物的Ⅱ相代谢产物及其药理作用进行了综述。

引用

页码：144 / 150

页数：7

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