阿托伐他汀对动脉粥样硬化模型兔toll样受体4及其下游信号表达的影响

被引：6

作者：

李悦妍 ^{[1
]}

关玉庆 ^{[2
]}

苗伟 ^{[2
]}

户克庆 ^{[2
]}

胡鸿雁 ^{[3
]}

李莹 ^{[2
]}

王晓琦 ^{[2
]}

苏国海 ^{[2
]}

机构：

[1] 山东大学医学院

[2] 山东大学附属济南市中心医院心内科

[3] 山东大学附属济南市中心医院介入科

来源：

山东大学学报(医学版) | 2014年 / 52卷 / 06期

关键词：

阿托伐他汀; 动脉粥样硬化; Toll样受体4; 单核细胞趋化蛋白; 转化生长因子β;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）]; R972.6 [];

学科分类号：

1002 ; 100201 ; 1007 ;

摘要：

目的探讨短期内不同剂量阿托伐他汀对动脉粥样硬化家兔模型toll样受体4(TLR4)的表达及其下游信号单核细胞趋化蛋白(MCP-1)、转化生长因子β(TGF-β)血清水平的影响。方法 28只新西兰大白兔随机分为对照组(n=6)、模型组(n=6)、阿托伐他汀低剂量组(n=8)和阿托伐他汀高剂量组(n=8)。除对照组外其他各组均通过8周高脂喂养联合腹主动脉球囊损伤术建立动脉粥样硬化模型。8周后,模型组继续高脂喂养,阿托伐他汀低、高剂量两组在高脂喂养的同时分别给予不同剂量药物干预2周。10周处死所有动物。静脉血测定血清血脂水平及ELISA法测定炎性因子MCP-1、TGF-β的血清水平。HE、Masson染色和天狼猩红染色观察血管病理变化及胶原纤维含量,免疫组化检测TLR4的表达水平。结果对照组血脂水平和炎性因子MCP-1水平明显低于其他各组(P<0.05),TGF-β水平明显高于其他各组(P<0.05)。阿托伐他汀低、高剂量两组血脂及MCP-1水平明显低于模型组(P<0.05),TGF-β水平明显高于模型组(P<0.05),且高剂量组变化更加明显(P<0.01)。对照组TLR4的表达明显低于其他各组(P<0.05),阿托伐他汀低、高剂量组显著低于模型组(P<0.05),且高剂量他汀组比低剂量组降低更为显著(P<0.01)。结论阿托伐他汀可在短期内降低血脂,同时通过减少TLR4的表达及调节下游信号MCP-1、TGF-β的释放发挥抗动脉粥样硬化作用,且具有剂量依赖性。

引用

页码：1 / 6

页数：6

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