醋甲唑胺片致Stevens-Johnson综合征

被引：9

作者：

闫成

薛洪源

蔡长春

机构：

[1] 解放军白求恩国际和平医院药剂科

来源：

中国药物应用与监测 | 2012年 / 9卷 / 03期

关键词：

醋甲唑胺; Stevens-Johnson综合征; 药品不良反应;

D O I：

暂无

中图分类号：

R595.3 [药源性疾病];

学科分类号：

100201 [内科学];

摘要：

1例33岁男性患者,因右眼被石头砸伤1 d入院,诊断为右眼钝挫伤、继发性青光眼。予以口服醋甲唑胺片25 mg,tid降眼压治疗,10 d后停药,行右眼巩膜下巩膜咬切术。术后第三日,患者出现面颈部皮疹,迅速波及全身,起初表现为红斑、丘疹,痒感明显,继而出现水疱、大疱、表皮松解剥脱,口腔、咽、眼黏膜受损、糜烂,伴渗出,同时存在高热、头痛、乏力等症状,考虑药源性Stevens-Johnson综合征,停用可疑药物,给予盐酸西替利嗪分散片、甲泼尼龙琥珀酸钠、人免疫球蛋白、盐酸去甲万古霉素等治疗,3周后,皮疹明显好转。

引用

页码：179 / 181

页数：3

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