氨甲环酸在全髋关节置换术围手术期疗效与安全性的meta分析

被引：10

作者：

周磊

李涛

翁习生

蒋超

翟吉良

彭慧明

机构：

[1] 中国医学科学院北京协和医学院北京协和医院骨科

来源：

中国骨与关节外科 | 2013年 / 6卷 / 05期

关键词：

氨甲环酸; meta分析; 全髋关节置换术; 失血; 异体输血;

D O I：

暂无

中图分类号：

R687.4 [关节手术];

学科分类号：

1002 ; 100210 ;

摘要：

背景:目前针对氨甲环酸(TXA)能否安全有效地降低全髋关节置换术(THA)的失血量和输血率尚未达成共识。目的:通过meta分析评价TXA在THA围手术期应用的有效性和安全性。方法:检索2003年至2013年PubMed、Medline、EMBase、Cochrane library、CNKI和万方数据知识服务平台中发表的有关TXA在THA中应用的相关临床随机对照研究,对TXA组与对照组术中失血量、术后失血量、总失血量、异体输血率及静脉血栓栓塞症(VTE)发生率进行meta分析。结果:筛选出符合纳入标准的高质量随机对照研究9篇,共460例(460髋)。与对照组比较,TXA可减少THA患者的术中失血量[WMD=-87.04,95%C(I-148.54,-25.55),P=0.006],术后失血量[WMD=-123.35,95%C(I-215.04,-31.66),P=0.008],总失血量[WMD=-247.74,95%C(I-350.60,-144.89),P<0.00001],降低输血率[OR=0.34,95%C(I0.21,0.55),P<0.0001],而VTE发生率无明显差异。结论:TXA可明显减少THA围手术期失血量,降低输血率,同时不增加发生VTE的风险。

引用

页码：421 / 426

页数：6

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