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ZD1839 (’Iressa’), a selective oral EGFR-TKI( epidermal growth factor receptor tyro sine kinase inhibitor) is well tolerated and active in patients with solid, malignant tumors: results of a phase 1111111111 trial. Ranson M,Hammond L,Ferry D,et al. Journal of Clinical Oncology . 2002
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Studies leading to the i dentification of ZD1839( IRESSA) : an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer. Barker AJ .Gibson KH,Grundy W,et al. Bioorganic and Medicinal Chemistry . 2001
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Quantitative assay of epidermal growth rceptor in squamous cell lung carcinomas. Gorgoulis V,Aninos D,Mikou P,et al. Anticancer Research . 1992
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Pharmacokinetics and tolerability of the orally active selective epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in healthy volunteers. Swaisland H,Laight A,Stafford L,et al. Clinical Pharmacokinetics . 2001
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Detection of human papil lomavirus deoxyribonucleic acid in penile carcinoma by poly-merase chain reaction and in situ hybridization. Iwasawa A,Kumamoto Y,Fujinaga K. Journal d Urologie . 1993