细胞凋亡的调控与Ⅰ型糖尿病

被引：5

作者：

邓利娟

陈慎仁

机构：

[1] 汕头大学医学院第二附属医院内分泌科,汕头大学医学院第二附属医院内分泌科广东汕头,广东汕头

来源：

中国病理生理杂志 | 2002年 / 09期

关键词：

细胞凋亡; Caspases; 基因,bcl-2; 糖尿病,胰岛素依赖型;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

1002 ; 100201 ;

摘要：

Apoptosis, also known as programmed cell death,is a normal process contributing to tissue tumor during development and in the adult.During development apoptosis is involved in tissue homeostasis and eliminating nonfunctional,superfluous or harmful cells.It is an active process controlled by some gene and factors such as caspases, bcl-2, Fas/FasL and NO.Type 1 diabetes mellitus is regarded as a chronic autoimmune disease resulting from progressive destruction of insulin-producing β-cells in the pancreas.The relationship between apoptosis with its modulation and type 1 diabetes mellitus was reviwed.

引用

页码：142 / 145

页数：4

共 31 条

[1]

Review: nuclear events in apoptosis. Robertson J D,John D R,Orrenius S B,et al. Journal of Structural Biology . 2000

[2] LOW BCL-2 EXPRESSION AND INCREASED SPONTANEOUS APOPTOSIS IN T-LYMPHOCYTES FROM NEWLY-DIAGNOSED IDDM PATIENTS [J].

GIORDANO, C ;

STASSI, G ;

TODARO, M ;

DEMARIA, R ;

RICHIUSA, P ;

SCORSONE, A ;

GIORDANO, M ;

GALLUZZO, A .

DIABETOLOGIA, 1995, 38 (08) :953-958

[3]

Diabetes[P]. 英国专利:GB201117172D0,2011-11-16

[4]

Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region. Colucci F,Bergman ML,Penha C et al. Proceedings of the National Academy of Sciences of the United States of America . 1997

[5]

Site- specific DNA methylation and apoptosis: induction by diabetogenic streptozocin. Mariko M,Takahashi A,Santo I,et al. Biochemical Pharmacology . 1999

[6]

Programmed cell death in the pathogenesis of murine IDDM: resistance to apoptosis induced in lymphocytes by cyclophosphamide. Colucci F,Cilio C M,Lejon K,et al. Journal of Autoimmunity . 1996

[7]

Diabetes[P]. 英国专利:GB201117172D0,2011-11-16

[8]

High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH(2)-terminal hinase and caspases-3. Ho FM,Lin SH,Liau CS,et al. Circulation . 2000

[9]

Diabetes-induced apoptosis in rat kidney. Zhang W,Khanna P,Chan II,et al. Biochemical and Molecular Medicine . 1997

[10]

Neurons undergo apoptosis in animal and cell culture models of diabetes. Russell JW,Sullivan KA,W indebank AJ,et al. Neurobiol D is . 1999

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