外泌体的功能及其在肿瘤诊疗中的应用

被引：5

作者：

鲁悦 ^{[1
]}

戴琪 ^{[1
]}

武鑫 ^{[2
]}

任福正 ^{[1
]}

机构：

[1] 华东理工大学药学院

[2] 上海维洱实验室

来源：

药学服务与研究 | 2019年 / 19卷 / 03期

关键词：

外泌体; 肿瘤靶向诊疗; 生物标记物; 药物传递系统; 综述;

D O I：

暂无

中图分类号：

R730 [一般性问题];

学科分类号：

100214 [肿瘤学];

摘要：

外泌体广泛存在于各种体液中,是一种由细胞主动分泌的膜囊泡,直径为40～100 nm。外泌体中包含的生物大分子积极参与肿瘤细胞间的信息传递,参与并调控肿瘤的发生、发展。研究表明,将外泌体作为肿瘤检测的生物标记物是一种更加灵敏、准确的肿瘤诊断方法,且外泌体的结构和粒径赋予其天然的载药优势,是一种前景广阔的靶向药物载体。本文从外泌体的结构和功能入手,详细综述国内外关于外泌体在肿瘤靶向诊疗及药物传递系统开发中的研究进展。

引用

页码：172 / 174+179 +179

页数：4

共 11 条

[1]

Extracellular vesicles as new players in angiogenesis.[J].Sharad Kholia;Andrea Ranghino;Paolo Garnieri;Tatiana Lopatina;Maria Chiara Deregibus;Pietro Rispoli;Maria Felice Brizzi;Giovanni Camussi.Vascular Pharmacology.2016,

[2]

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time.[J].S.A.A. Kooijmans;L.A.L. Fliervoet;R. van der Meel;M.H.A.M. Fens;H.F.G. Heijnen;P.M.P. van Bergen en Henegouwen;P. Vader;R.M. Schiffelers.Journal of Controlled Release.2016,

[3]

Combined evaluation of a panel of protein and miRNA serum-exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity [J].

Madhavan, Bindhu ;

Yue, Shijing ;

Galli, Uwe ;

Rana, Sanyukta ;

Gross, Wolfgang ;

Mueller, Miryam ;

Giese, Nathalia A. ;

Kalthoff, Holger ;

Becker, Thomas ;

Buechler, Markus W. ;

Zoeller, Margot .

INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (11) :2616-2627

[4]

Identification of Endogenous Controls for Analyzing Serum Exosomal miRNA in Patients with Hepatitis B or Hepatocellular Carcinoma.[J].Yi Li;Liqun Zhang;Fei Liu;Guiming Xiang;Dongneng Jiang;Xiaoyun Pu;Kishore Chaudhry.Disease Markers.2015,

[5]

Pathologic function and therapeutic potential of exosomes in cardiovascular disease [J].

Ailawadi, Shaina ;

Wang, Xiaohong ;

Gu, Haitao ;

Fan, Guo-Chang .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2015, 1852 (01) :1-11

[6]

Identification of cell-free microRNAs in the urine of patients with prostate cancer [J].

Korzeniewski, Nina ;

Tosev, Georgi ;

Pahernik, Sascha ;

Hadaschik, Boris ;

Hohenfellner, Markus ;

Duensing, Stefan .

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2015, 33 (01) :16.e17-16.e22

[7]

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery.[J].Luisa Pascucci;Valentina Coccè;Arianna Bonomi;Diletta Ami;Piero Ceccarelli;Emilio Ciusani;Lucia Viganò;Alberta Locatelli;Francesca Sisto;Silvia Maria Doglia;Eugenio Parati;Maria Ester Bernardo;Maurizio Muraca;Giulio Alessandri;Gianpietro Bondiolotti;Augusto Pessina.Journal of Controlled Release.2014,

[8]

Neoplastic Reprogramming of Patient-Derived Adipose Stem Cells by Prostate Cancer Cell-Associated Exosomes [J].

Abd Elmageed, Zakaria Y. ;

Yang, Yijun ;

Thomas, Raju ;

Ranjan, Manish ;

Mondal, Debasis ;

Moroz, Krzysztof ;

Fang, Zhide ;

Rezk, Bashir M. ;

Moparty, Krishnarao ;

Sikka, Suresh C. ;

Sartor, Oliver ;

Abdel-Mageed, Asim B. .

STEM CELLS, 2014, 32 (04) :983-997

[9]

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy [J].

Tian, Yanhua ;

Li, Suping ;

Song, Jian ;

Ji, Tianjiao ;

Zhu, Motao ;

Anderson, Gregory J. ;

Wei, Jingyan ;

Nie, Guangjun .

BIOMATERIALS, 2014, 35 (07) :2383-2390

[10]

The EPR effect: Unique features of tumor blood vessels for drug delivery; factors involved; and limitations and augmentation of the effect.[J].Jun Fang;Hideaki Nakamura;Hiroshi Maeda.Advanced Drug Delivery Reviews.2010, 3

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