颈椎小关节源性疼痛机制的神经生物学研究进展

被引：9

作者：

唐峰

谢宁

机构：

[1] 第二军医大学附属长征医院脊柱外科

来源：

中国骨科临床与基础研究杂志 | 2015年 / 7卷 / 05期

关键词：

颈椎; 关节疾病; 疼痛; 神经生物学; 疼痛感受器; 神经递质; 细胞因子类; 神经肽类;

D O I：

暂无

中图分类号：

R681.55 [];

学科分类号：

摘要：

颈椎小关节疾病是颈部慢性疼痛的常见来源,临床上较为关注其诊断的精确性和稳定性,而对病理生理及疼痛机制,特别是相关神经生物学研究缺乏足够的认识。该文从疼痛产生的细胞学水平层面对颈椎小关节源性疼痛这一由多种炎性因子及神经递质参与调节及维持的综合反应进行综述:介绍颈椎小关节神经支配及其疼痛感受器的分布情况,阐述慢性损伤后小关节发生的不可逆的神经病理变化(包括神经元激活、炎性因子释放和神经元免疫表型改变等),并重点介绍其中参与疼痛启动与维持的疼痛传入递质、应激相关蛋白和局部炎性因子、脊髓谷氨酸等三大类神经递质和肽类。

引用

页码：298 / 304

页数：7

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