绝经后2型糖尿病患者骨密度的影响因素和骨质疏松患病率

被引：12

作者：

莫慧

刘石平

周智广

李建伟

陈晶

机构：

[1] 中南大学湘雅二医院代谢内分泌研究所中南大学糖尿病中心

来源：

中国老年学杂志 | 2008年 / 19期

关键词：

绝经后; 2型糖尿病; 骨密度; 骨质疏松;

D O I：

暂无

中图分类号：

R587.1 [糖尿病]; R580 [];

学科分类号：

摘要：

目的探讨绝经后2型糖尿病(T2DM)患者骨密度(BMD)的影响因素及其与糖尿病微血管并发症的相关性。方法对符合纳入标准的197例绝经后T2DM患者的住院资料进行回顾性分析。结果①多元逐步回归分析示,体重指数、年龄和绝经年限是影响腰椎和髋部BMD的主要因素。②低体重组的BMD低于正常体重组、超重组和肥胖组(P<0.05或P<0.01),其骨质疏松(OP)患病率为100%,显著高于肥胖组(69%)(P<0.0)。③绝经年限≥6年组的BMD明显低于绝经年限<6年组的BMD(P<0.01),其OP患病率为88%,也显著高于绝经年限<6年组(55%)(P<0.0)。④随着尿白蛋白排泄量的增加,BMD逐渐下降,但组间BMD和OP患病率无统计学差异。⑤并发视网膜病变组其髋部BMD明显低于未并发视网膜病变组(P<0.05),前者OP患病率为91%,显著高于后者(75%)(P<0.0)。结论绝经年限长、体重低、并发糖尿病微血管病变或高龄的绝经后T2DM妇女BMD低,易发生OP。

引用

页码：1921 / 1924

页数：4

共 22 条

[1] Investigation of the relationship between type 2 diabetes and osteoporosis using Bayesian inference
Romana, M. Sta.
Li-Yu, J. T.
[J]. JOURNAL OF CLINICAL DENSITOMETRY, 2007, 10 (04) : 386 - 390
[2] A study of bone mineral density in diabetes mellitus in eastern India. Chakrabarty N,,Sarkar P,,Pal SK,et al. Journal of the Indian Medical Association . 2004
[3] Type 1 and type 2 d iabetesand inc ident h ip fractures in postm enopausal wom en. N icodemus KN,Folsom AR. Diabetes Care . 2001
[4] Boneturnoverand bodyweightrelationshipsdifferinnormal weightcomparedwith heavierpostmenopausalwomen. CifuentesM,JohnsonMA,LewisRD,etal. Osteoporosis International . 2003
[5] Serumpentosidine levels are positively associated with the presence of vertebral fractures in post-menopausal women with type2diabetes. Yamamoto M,Yamaguchi T,Yamauchi M,et al. The Journal of Clinical Endocrinology . 2008
[6] DIABETIC MEDICINE[P]. UCHIYAMA TSUTOMU.日本专利:JP2007314465A,2007-12-06
[7] Fracture risk in type2dia-betes:update of a population-based study. Melton LJ,Leibson CL,Achenbach SJ,et al. Journal of Bone and Mineral Research . 2008
[8] Body mass index as a predictor of fracture risk:a meta-analysis. De Laet C,Kanis JA,Odn A,et al. Osteoporosis International . 2005
[9] Investigation of the relationship between type2diabetes and osteoporosis using bayesian inference. Sta Romana M,Li-Yu JT. Journal of Clinical Densitometry . 2007
[10] Osteoporosis among patients with type1and type2diabetesV. Rakel A,Sheehy O,Rahme E,et al. Diabetes and Metabolism . 2008

← 1 2 3 →