Critical illness polyneuropathy and myopathy:a systematic review

被引：25

作者：

Chunkui Zhou ^{[1
,2
]}

Limin Wu ^{[1
,3
]}

Fengming Ni ^{[4
]}

Wei Ji ^{[5
]}

Jiang Wu ^{[1
]}

Hongliang Zhang ^{[1
]}

机构：

[1] Department of Neurology,the First Bethune Hospital,Jilin University

[2] Department of Neurology,the Second Part,the First Bethune Hospital,Jilin University

[3] Neuroprotection Research Laboratory,Massachusetts General Hospital,Harvard Medical School

[4] Department of Radiotherapy,Oncology Center,the First Bethune Hospital,Jilin University

[5] Department of Vascular Surgery,People’s Hospital of Jilin Province

来源：

Neural Regeneration Research | 2014年 / 9卷 / 01期

关键词：

D O I：

暂无

中图分类号：

R746 [神经肌肉疾病];

学科分类号：

100204 [神经病学];

摘要：

Critical illness polyneuropathy and critical illness myopathy are frequent complications of severe illness that involve sensorimotor axons and skeletal muscles,respectively.Clinically,they manifest as limb and respiratory muscle weakness.Critical illness polyneuropathy/myopathy in isolation or combination increases intensive care unit morbidity via the inability or difficulty in weaning these patients off mechanical ventilation.Many patients continue to suffer from decreased exercise capacity and compromised quality of life for months to years after the acute event.Substantial progress has been made lately in the understanding of the pathophysiology of critical illness polyneuropathy and myopathy.Clinical and ancillary test results should be carefully interpreted to differentiate critical illness polyneuropathy/myopathy from similar weaknesses in this patient population.The present review is aimed at providing the latest knowledge concerning the pathophysiology of critical illness polyneuropathy/myopathy along with relevant clinical,diagnostic,differentiating,and treatment information for this debilitating neurological disease.

引用

页码：101 / 110

页数：10