姜黄素纳米结构脂质载体的药动学

被引：16

作者：

万坤

孙立力

胡雪原

杨梅

张景勍

机构：

[1] 重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室

来源：

中成药 | 2014年 / 36卷 / 12期

关键词：

姜黄素; 纳米脂质体; 药代动力学; 大鼠血浆;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

目的建立测定大鼠血浆中姜黄素的HPLC法,并研究姜黄素纳米脂质体大鼠灌胃给药后的药动学行为。方法 12只SD大鼠随机分成2组,单剂量灌胃给予纳米脂质体及游离姜黄素后,采用HPLC法测定血浆中药物浓度,计算药代动力学参数。结果建立了姜黄素在大鼠血浆中的测定方法。结果表明纳米脂质体在大鼠体内吸收迅速,清除率降低,其AUC(0-t)为(930.08±18.95)μg·h/L,t1/2为(10.71±3.30)h,Cmax为(117.57±4.61)μg/L,相对于游离药物,纳米脂质体的生物利用度提高了约800%。结论纳米脂质体是姜黄素较好的递送系统,HPLC法可用于大鼠血浆姜黄素测定及药代动力学研究。

引用

页码：2503 / 2507

页数：5

共 11 条

[1]

Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery.[J].Patrícia Severino;Tatiana Andreani;Ana Sofia Macedo;Joana F. Fangueiro;Maria Helena A. Santana;Amélia M. Silva;Eliana B. Souto;Rajesh Patil.Journal of Drug Delivery.2011,

[2]

Lipid nanoparticles with different oil/fatty ester ratios as carriers of buprenorphine and its prodrugs for injection [J].

Wang, Jhi-Joung ;

Liu, Kuo-Sheng ;

Sung, K. C. ;

Tsai, Chia-Yin ;

Fang, Jia-You .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 38 (02) :138-146

[3]

Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC–MS/MS.[J].Kuo-Yi Yang;Lei-Chwen Lin;Ting-Yu Tseng;Shau-Chun Wang;Tung-Hu Tsai.Journal of Chromatography B.2007, 1

[4]

The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-γ [J].

Siddiqui, Aqeel M. ;

Cui, Xiaoxuan ;

Wu, Rongqian ;

Dong, Weifeng ;

Zhou, Mian ;

Hu, Maowen ;

Simms, H. Hank ;

Wang, Ping .

CRITICAL CARE MEDICINE, 2006, 34 (07) :1874-1882

[5]

Pharmacokinetics of DTPA entrapped in conventional and long-circulating liposomes of different size for plutonium decorporation [J].

Phan, G ;

Herbet, A ;

Cholet, S ;

Benech, H ;

Deverre, JR ;

Fattal, E .

JOURNAL OF CONTROLLED RELEASE, 2005, 110 (01) :177-188

[6]

Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics.[J].Nasir Hussain;Vikas Jaitley;Alexander T Florence.Advanced Drug Delivery Reviews.2001, 1

[7]

Solid lipid nanoparticles in lymph and plasma after duodenal administration to rats [J].